	US 12,329,137 B2
	Method of preparing mouse model of herpes
Seonghyang Sohn, Suwon (KR)
Assigned to AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION, Suwon-si (KR)
Appl. No. 17/622,364
Filed by AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION, Suwon-si (KR)
PCT Filed Jun. 25, 2020, PCT No. PCT/KR2020/008248 § 371(c)(1), (2) Date Dec. 23, 2021, PCT Pub. No. WO2020/262972, PCT Pub. Date Dec. 30, 2020.
Claims priority of application No. 10-2019-0075872 (KR), filed on Jun. 25, 2019.
Prior Publication US 2022/0232811 A1, Jul. 28, 2022
Int. Cl. A01K 67/027 (2024.01)

CPC A01K 67/027 (2013.01) [A01K 2207/20 (2013.01); A01K 2227/105 (2013.01); A01K 2267/03 (2013.01)]

5 Claims

1. A method of preparing a mouse model of herpes, the method comprising:

(a) damaging a site of surface of a mouse, inoculating the damaged site with herpes simplex virus type 1 (HSV-1), and then rearing the mouse; and

(b) injecting the reared mouse with hydrocortisone,

wherein the injection of hydrocortisone to the mouse is performed every day for 3 to 10 consecutive days from the day after the inoculation with herpes simplex virus type 1 has been completed, and

wherein an amount of hydrocortisone injected is 75 μg/day to 300 μg/day per average body weight of mice, said average body weight being 25 g.