US 12,010,467 B2
Method and system for whole slide imaging
Prarthana Shrestha, Eindhoven (NL); Jelte Peter Vink, Waalre (NL); Maarten Van Lierop, Rosmalen (NL); Gerardus Johannes Wilhelmus Van Den Braak, Eindhoven (NL); Mathijs Rem, Eindhoven (NL); and Jeroen De Kleijn, Eindhoven (NL)
Assigned to KONINKLIJKE PHILIPS N.V., Eindhoven (NL)
Appl. No. 17/790,291
Filed by KONINKLIJKE PHILIPS N.V., Eindhoven (NL)
PCT Filed Dec. 24, 2020, PCT No. PCT/EP2020/087847
§ 371(c)(1), (2) Date Jun. 30, 2022,
PCT Pub. No. WO2021/136740, PCT Pub. Date Jul. 8, 2021.
Claims priority of application No. 19220155 (EP), filed on Dec. 31, 2019.
Prior Publication US 2023/0104460 A1, Apr. 6, 2023
Int. Cl. H04N 9/67 (2023.01); G02B 21/36 (2006.01); G06T 7/90 (2017.01)
CPC H04N 9/67 (2013.01) [G02B 21/365 (2013.01); G06T 7/90 (2017.01); G06T 2207/10024 (2013.01); G06T 2207/10056 (2013.01); G06T 2207/30024 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A method for obtaining an adapted calibration transformation for whole slide imaging, wherein the adapted calibration transformation is for outputting the color of an empty area of the slide in a whole slide image, WSI, obtained by a scanner as a desired color in a device-independent color space, the method comprising:
receiving a color target WSI in a device-dependent color space, wherein the color target WSI is a WSI of a color target from the scanner represented in the device-dependent color space and wherein the color target contains at least a white patch and three color patches;
obtaining a calibration transformation for transforming the device-dependent color space to the device-independent color space;
determining a chromatic adaptation transformation based on the color of the white patch in the device-dependent color space, the color of the empty area in the device-dependent color space and the desired color in a target color space; and
obtaining an adapted calibration transformation based on applying the chromatic adaptation transformation to the calibration transformation; wherein obtaining a calibration transformation is based on calibrating the scanner by mapping a set of scanner acquired raw RGB values from the color target with a set of reference colorimetric values and obtaining a calibration transformation.