US 12,007,354 B2
Rapid detection and identification of bacteria with graphene field effect transistors and peptide probes
Kenneth S. Burch, Brighton, MA (US); Tim van Opijnen, Somerville, MA (US); Jianmin Gao, Newton, MA (US); Narendra Kumar, Brighton, MA (US); Juan C. Ortiz-Marquez, Brighton, MA (US); Wenjian Wang, Brighton, MA (US); and Mason Gray, Chestnut Hill, MA (US)
Assigned to The Trustees of Boston College, Chestnut Hill, MA (US)
Filed by Kenneth S. Burch, Brighton, MA (US); Tim van Opijnen, Somerville, MA (US); Jianmin Gao, Newton, MA (US); Narendra Kumar, Brighton, MA (US); Juan C. Ortiz-Marquez, Brighton, MA (US); Wenjian Wang, Brighton, MA (US); and Mason Gray, Chestnut Hill, MA (US)
Filed on Nov. 6, 2020, as Appl. No. 17/090,982.
Claims priority of provisional application 62/932,832, filed on Nov. 8, 2019.
Prior Publication US 2021/0140919 A1, May 13, 2021
Int. Cl. G01N 27/414 (2006.01)
CPC G01N 27/4145 (2013.01) [G01N 27/4146 (2013.01); G01N 27/4148 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A label-free bacteria detection system, comprising:
a graphene field effect transistor (G-FET)/peptide device capable of biosensing using dielectrophoresis and comprising a peptide probe formed of a chemically modified peptide conjugated to a flat aromatic linker and capable of recognizing and binding to a bacterial target integrated on the G-FET, wherein the G-FET comprises a defect-free graphene monolayer fabricated into a field effect transistor having electrical contacts insulated from a defined sensing area.