US 12,006,592 B2
Vascular constructs
Sang Jin Lee, Winston-Salem, NC (US); James J. Yoo, Winston-Salem, NC (US); Young Min Ju, Winston-Salem, NC (US); and Anthony Atala, Winston-Salem, NC (US)
Assigned to Wake Forest University Health Sciences, Winston-Salem, NC (US)
Filed by Wake Forest University Health Sciences, Winston-Salem, NC (US)
Filed on May 10, 2021, as Appl. No. 17/316,342.
Application 17/316,342 is a continuation of application No. 16/171,504, filed on Oct. 26, 2018, granted, now 11,028,502.
Claims priority of provisional application 62/580,770, filed on Nov. 2, 2017.
Prior Publication US 2021/0269943 A1, Sep. 2, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. D01D 5/00 (2006.01); A61K 31/728 (2006.01); A61K 31/729 (2006.01); A61K 31/737 (2006.01); A61K 35/44 (2015.01); A61K 38/18 (2006.01); A61K 38/36 (2006.01); A61K 38/39 (2006.01); A61L 27/24 (2006.01); C07D 315/00 (2006.01); C07K 16/18 (2006.01); C07K 16/28 (2006.01); C07K 16/46 (2006.01); D01F 1/10 (2006.01); D01F 6/92 (2006.01); D01F 4/00 (2006.01); D01F 6/62 (2006.01)
CPC D01D 5/003 (2013.01) [A61K 31/728 (2013.01); A61K 31/729 (2013.01); A61K 31/737 (2013.01); A61K 35/44 (2013.01); A61K 38/1858 (2013.01); A61K 38/363 (2013.01); A61K 38/39 (2013.01); A61L 27/24 (2013.01); C07D 315/00 (2013.01); C07K 16/18 (2013.01); C07K 16/289 (2013.01); C07K 16/46 (2013.01); D01D 5/0076 (2013.01); D01F 1/10 (2013.01); D01F 6/92 (2013.01); C07K 16/2896 (2013.01); D01F 4/00 (2013.01); D01F 6/625 (2013.01)] 36 Claims
OG exemplary drawing
 
1. A self-seeding vascular graft comprising an electrospun matrix having a hollow tubular shape with an outside surface and a lumen that is defined by an inside surface, the matrix having a three-dimensional ultrastructure of interconnected fibers, the fibers having an average diameter between 100 nanometer and 5 micrometers and wherein at least two different endothelial cell or endothelial progenitor cell (EC/EPC) specific antibodies are conjugated to the inner surface of the matrix.