US 12,006,541 B2
Methods and apparatuses for generating peptides by synthesizing a portion of a design space to identify peptides having non-canonical amino acids
Francis Lee, Cambridge, MA (US); Jonathan D. Steckbeck, Cranberry Township, PA (US); and Hannes Holste, Los Angeles, CA (US)
Assigned to Peptilogics, Inc., Pittsburgh, PA (US)
Filed by Peptilogics, Inc.c, Pittsburgh, PA (US)
Filed on Nov. 28, 2022, as Appl. No. 18/059,182.
Application 18/059,182 is a continuation of application No. 17/401,975, filed on Aug. 13, 2021, granted, now 11,512,345.
Claims priority of provisional application 63/185,841, filed on May 7, 2021.
Claims priority of provisional application 63/185,770, filed on May 7, 2021.
Prior Publication US 2023/0161844 A1, May 25, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C12Q 1/6869 (2018.01); G06F 18/21 (2023.01); G06F 18/214 (2023.01); G06N 20/20 (2019.01); G16B 30/00 (2019.01); G16B 35/10 (2019.01); G16B 40/00 (2019.01)
CPC C12Q 1/6869 (2013.01) [G06F 18/214 (2023.01); G06F 18/217 (2023.01); G06N 20/20 (2019.01); G16B 30/00 (2019.02); G16B 35/10 (2019.02); G16B 40/00 (2019.02)] 20 Claims
OG exemplary drawing
 
1. A computer-implemented automated flow synthesis platform configured to use an artificial intelligence (AI) engine and comprising:
a reaction chamber configured to synthesize a sequence;
one or more detectors configured to monitor the synthesis of the sequence in the reaction chamber, wherein the synthesis uses an automated flow process; and
a computing device communicatively coupled to the one or more detectors, wherein the computing device is configured to:
receive one or more measurements from the one or more detectors, wherein the one or more measurements comprise a spectral profile at each coupling of each amino acid in the sequence;
determine, using one or more trained machine learning models, a synthesizing recipe that enables the sequence to be synthesized, wherein the synthesizing recipe comprises one or more parameters used to control at least the reaction chamber during the automated flow process to synthesize the sequence; and
control, using the synthesizing recipe, the synthesis of the sequence in the reaction chamber.