Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis
Jingyue Ju, Englewood Cliffs, NJ (US); Xiaoxu Li, New York, NY (US); Xin Chen, New York, NY (US); Zengmin Li, Flushing, NY (US); Shiv Kumar, Belle Meade, NJ (US); Shundi Shi, Ozone Park, NY (US); Cheng Guo, Brooklyn, NY (US); Jianyi Ren, New York, NY (US); Min-Kang Hsieh, New York, NY (US); Minchen Chien, Tenafly, NJ (US); Chuanjuan Tao, Fort Lee, NJ (US); Ece Erturk, New York, NY (US); Sergey Kalachikov, Bronx, NY (US); and James J. Russo, New York, NY (US)
Assigned to THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, New York, NY (US)
Filed by The Trustees of Columbia University in the City of New York, New York, NY (US)
Filed on Aug. 1, 2022, as Appl. No. 17/816,555.
Application 17/816,555 is a continuation of application No. 17/373,295, filed on Jul. 12, 2021.
Application 17/373,295 is a continuation of application No. 15/763,364, granted, now 11,085,076, issued on Aug. 10, 2021, previously published as PCT/US2016/054236, filed on Sep. 28, 2016.
Claims priority of provisional application 62/257,102, filed on Nov. 18, 2015.
Claims priority of provisional application 62/233,950, filed on Sep. 28, 2015.
Prior Publication US 2023/0028388 A1, Jan. 26, 2023
1. A nucleotide analogue comprising (i) a base, (ii) a deoxyribose or ribose, and (iii) a detectable label bound to the base via a linker, wherein said linker has the formula:
