US 12,006,498 B2
Composition for regulating expression of PROX1 or expression of telomerase reverse transcriptase comprising activity regulator or method for screening telomerase reverse transcriptase regulator
Sang Hoon Jung, Gangneung-si (KR); Young-Joo Kim, Gangneung-si (KR); Dae-geun Song, Gangneung-si (KR); Young Nyun Park, Seoul (KR); Jeong Eun Yoo, Incheon (KR); Hyung Jin Rhee, Seoul (KR); and Youngsic Jeon, Seoul (KR)
Assigned to KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY, Seoul (KR); and INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY, Seoul (KR)
Appl. No. 16/761,151
Filed by KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY, Seoul (KR); and INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY, Seoul (KR)
PCT Filed Oct. 19, 2018, PCT No. PCT/KR2018/012383
§ 371(c)(1), (2) Date Jun. 2, 2020,
PCT Pub. No. WO2019/088528, PCT Pub. Date May 9, 2019.
Claims priority of application No. 10-2017-0146274 (KR), filed on Nov. 3, 2017.
Prior Publication US 2023/0250424 A1, Aug. 10, 2023
Int. Cl. C12N 15/113 (2010.01); A61P 1/16 (2006.01); A61P 35/00 (2006.01)
CPC C12N 15/113 (2013.01) [A61P 1/16 (2018.01); A61P 35/00 (2018.01); C12N 2310/11 (2013.01); C12N 2310/12 (2013.01); C12N 2310/127 (2013.01); C12N 2310/14 (2013.01); C12N 2310/141 (2013.01); C12N 2310/3181 (2013.01); C12N 2310/531 (2013.01)] 7 Claims
OG exemplary drawing
 
1. A method for regulating expression of telomerase reverse transcriptase (TERT), comprising administering a composition comprising a prospero homeobox protein 1 (PROX1) expression or activity regulator to a subject in need thereof;
wherein the PROX1 expression or activity regulator is a siRNA represented by SEQ. ID. NO.: 1, SEQ. ID. NO.: 2, a sequence having 70% or higher homology to SEQ. ID. NO.: 1, or a sequence having 70% or higher homology to SEQ. ID. NO.: 2.