	US 12,006,350 B2
	Triblock peptide amphiphiles, micelles and methods of use
Bret Ulery, Columbia, MO (US); Rui Zhang, Columbia, MO (US); Caitlin Leeper, Columbia, MO (US); Josiah Smith, Columbia, MO (US); and Logan Morton, Columbia, MO (US)
Assigned to The Curators of the University of Missouri, Columbia, MO (US)
Appl. No. 16/760,329
Filed by Bret Ulery, Columbia, MO (US); Rui Zhang, Columbia, MO (US); Caitlin Leeper, Columbia, MO (US); Josiah Smith, Columbia, MO (US); and Logan Morton, Columbia, MO (US)
PCT Filed Oct. 30, 2018, PCT No. PCT/US2018/058200 § 371(c)(1), (2) Date Apr. 29, 2020, PCT Pub. No. WO2019/089584, PCT Pub. Date May 9, 2019.
Claims priority of provisional application 62/578,843, filed on Oct. 30, 2017.
Prior Publication US 2020/0339661 A1, Oct. 29, 2020
Int. Cl. C07K 14/77 (2006.01); A61P 29/00 (2006.01); A61P 31/16 (2006.01); C07K 14/575 (2006.01); A61K 38/00 (2006.01)

CPC C07K 14/77 (2013.01) [A61P 29/00 (2018.01); A61P 31/16 (2018.01); C07K 14/57563 (2013.01); A61K 38/00 (2013.01)]

34 Claims

1. A triblock peptide of the formula:

A-B-C

wherein

A is a lipid moiety, wherein the lipid moiety is PalmK or Palm2K; and

B and C are independently a peptide block or a zwitterion-like block, wherein one of B and C is a peptide block and the other of B and C is a zwitterion-like block;

wherein the peptide block is selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, or SEQ ID NO: 4;

wherein the zwitterion-like block is (EK)₄or (KE)₄; and

wherein the triblock peptide assembles into a micelle when in a liquid.