CPC C07D 401/04 (2013.01) [C07D 217/06 (2013.01); C07D 217/08 (2013.01); C07D 223/16 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 403/10 (2013.01); C07D 405/06 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 417/06 (2013.01)] | 41 Claims |
1. A compound of Formula (I):
![]() or a solvate or pharmaceutically acceptable salt thereof, wherein
X1 is absent, —(CR3R4)q—, —O—, —S(O)2—, —C(O)—, —C(S)—, —S(O)—, —NR3C(O)—, —C(O)NR3—, —C(O)O—, or —OC(O)—;
X2 is absent, —(CR3R4)q—, —O—, —S(O2)—, —C(O)—, —C(S)—, —S(O)—, —NR3C(O)—, —C(O)NR3—, —C(O)O—, or —OC(O)—;
R1 is H, OH, halogen, NH2, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 alkoxyl, C1-C6 haloalkoxyl, C3-C6 cycloalkyl, C6-C10 aryl, 5- to 12-membered heteroaryl comprising 1-6 heteroatoms selected from N, O, and S, 5- to 14-membered saturated or unsaturated heterocycloalkyl comprising 1-5 heteroatoms selected from N, O, and S; wherein the alkyl, alkenyl, alkynyl, haloalkyl, alkoxyl, haloalkoxyl, cycloalkyl, aryl, heteroaryl, or heterocycloalkyl of any of the foregoing is optionally substituted with one or more R5;
R2 is C6-C10 aryl, 5- to 12-membered heteroaryl comprising 1-6 heteroatoms selected from N, O, and S, or 5- to 14-membered saturated or unsaturated heterocycloalkyl comprising 1-5 heteroatoms selected from N, O, and S; wherein the aryl, heteroaryl, or heterocycloalkyl of any of the foregoing is optionally substituted with one or more R6;
each R3 independently is H, halogen, or C1-C6 alkyl;
each R4 independently is H, halogen, or C1-C6 alkyl;
each R5 independently is OH, halogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 alkoxyl, C1-C6 haloalkoxyl, C3-C6 cycloalkyl, C6-C10 aryl, or 5- to 14-membered saturated or unsaturated heterocycloalkyl comprising 1-5 heteroatoms selected from N, O, and S; wherein the alkyl, alkenyl, alkynyl, cycloalkyl, or aryl of any of the foregoing is optionally substituted with one or more —C(O)C1-C6alkyl, —C(O)OC1-C6alkyl, —C(O)NH2, —C(O)NHC1-C6alkyl, or —C(O)N(C1-C6alkyl)2;
each R6 independently is OH, halogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 alkoxyl, C1-C6 haloalkoxyl, C3-C6 cycloalkyl, C6-C10 aryl, or 5- to 14-membered saturated or unsaturated heterocycloalkyl comprising 1-5 heteroatoms selected from N, O, and S; wherein the alkyl, alkenyl, alkynyl, cycloalkyl, aryl, or heterocycloalkyl of any of the foregoing is optionally substituted with one or more —C(O)C1-C6 alkyl, —C(O)OC1-C6 alkyl, —C(O)NH2, —C(O)NHC1-C6 alkyl, or —C(O)N(C1-C6alkyl)2;
R7 is C1-C6 alkyl optionally substituted with one or more OH, halogen, or C1-C6 alkoxyl;
R8 is C1-C6 alkyl optionally substituted with one or more OH, halogen, or C1-C6 alkoxyl;
m is 1;
n is 2;
p is 1; and
each q independently is 1, 2, 3, or 4.
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