	US 12,005,383 B2
	Method for fluorinating a filter for a pipette tip, pipette tip, associated production method and pipette
Nicolas Batisse, Perignat les Sarlieve (FR); Marc Dubois, Clermont-Ferrand (FR); Jérémy Peyroux, Ussel (FR); and Béatrice Guieu Presle, Deuil-la-Barre (FR)
Assigned to GILSON SAS, Villiers-le-Bel (FR); UNIVERSITE CLERMONT AUVERGNE, Clermont-Ferrand (FR); SIGMA CLERMONT, Aubiere (FR); and CENTRE NATIONAL DE LA RECHERCHE, Paris (FR)
Appl. No. 16/969,288
Filed by GILSON SAS, Villiers-le-Bel (FR); UNIVERSITE CLERMONT AUVERGNE, Clermont-Ferrand (FR); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Paris (FR); and SIGMA CLERMONT, Aubiere (FR)
PCT Filed Feb. 18, 2019, PCT No. PCT/FR2019/050359 § 371(c)(1), (2) Date Aug. 12, 2020, PCT Pub. No. WO2019/162602, PCT Pub. Date Aug. 29, 2019.
Claims priority of application No. 1851441 (FR), filed on Feb. 20, 2018.
Prior Publication US 2021/0008478 A1, Jan. 14, 2021
Int. Cl. B01D 39/16 (2006.01); B01L 3/02 (2006.01); C08L 23/28 (2006.01)

CPC B01D 39/1692 (2013.01) [B01L 3/0217 (2013.01); C08L 23/283 (2013.01); B01D 2239/0428 (2013.01); B01D 2239/10 (2013.01); B01L 2300/0681 (2013.01)]

22 Claims

1. Method for fluorinating a filter for a pipette tip, this filter being formed by a porous solid polyolefin structure, characterized in that it comprises the following steps:

(a) placing the filter in an enclosure,

(b) creating a vacuum in the enclosure, and

in that the fluorination agent consists of difluorine F₂, in that the difluorine F₂is introduced into the enclosure at a partial pressure between 100 Pa and 10000 Pa, in that step (c) is conducted at a temperature between 0° C. and 100° C., and further comprising after step (c):

(e₁) creating a vacuum in the enclosure, followed by

(e₂) contacting the filter with dihydrogen or a mixture comprising dihydrogen, the dihydrogen or mixture comprising dihydrogen comprising dihydrogen being introduced in the gaseous state into the enclosure.