US 12,005,227 B2
Direct drug/therapeutic infusion via trans-vascular glymphatic system and method
W. Jeffrey Shakespeare, Macungie, PA (US); and Jared B. Smith, Macungie, PA (US)
Assigned to Product Realization Specialites, LLC, Macungie, PA (US)
Filed by Product Realization Specialties, LLC, Macungie, PA (US)
Filed on Oct. 6, 2021, as Appl. No. 17/494,917.
Prior Publication US 2023/0109150 A1, Apr. 6, 2023
Int. Cl. A61M 5/142 (2006.01); A61M 5/172 (2006.01); A61M 39/02 (2006.01)
CPC A61M 5/14276 (2013.01) [A61M 5/1723 (2013.01); A61M 2005/14284 (2013.01); A61M 2005/1726 (2013.01); A61M 2039/025 (2013.01); A61M 2202/0464 (2013.01); A61M 2205/0266 (2013.01); A61M 2205/3306 (2013.01); A61M 2205/50 (2013.01); A61M 2210/0693 (2013.01); A61M 2210/12 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A dopamine or other drug/therapeutics delivery and monitoring system for treatment of brain disease comprising:
a. an implantable titrator operatively connected to one or more selected regions of the brain via the glymphatic system and further comprising:
a micropump for controlled pumping of dopamine or other drug into the one or more regions of the brain responsive to dopamine levels in the withdrawn CSF in the region of the brain that are monitored by a dopamine sensor; and
a mixing chamber to combine withdrawn CSF with dopamine or other drug from a reservoir in the titrator to form a mixture for controlled delivery of the mixture into the brain region via the glymphatic system;
b. at least one microtube connected to the titrator for delivery of dopamine or other drug into the one or more selected regions of the brain wherein the microtube is inserted through an arterial wall for delivery of the dopamine or other drug into the one or more regions of the brain, allowing the glymphatic system to effectively distribute the dopamine or other drug/therapeutic to the necessary regions of the brain requiring therapy; and
c. a second microtube operably connected to the titrator for withdrawal of CSF from the one or more regions of the brain glymphatic system.