US 12,005,220 B2
Microneedle patch for immunostimulatory drug delivery
Reid Waldman, West Hartford, CT (US); Madeline DeWane, Hamden, CT (US); Ming Hua Lee, Chicago, IL (US); and Lauren Sweeney Durso, Washington, DC (US)
Assigned to Veradermics Incorporated, West Hartford, CT (US)
Filed by VERADERMICS INCORPORATED, San Antonio, TX (US)
Filed on Nov. 20, 2020, as Appl. No. 17/100,722.
Claims priority of provisional application 62/939,447, filed on Nov. 22, 2019.
Prior Publication US 2021/0154456 A1, May 27, 2021
Int. Cl. A61M 37/00 (2006.01); A61K 39/00 (2006.01); A61K 39/12 (2006.01)
CPC A61M 37/0015 (2013.01) [A61K 39/0002 (2013.01); A61K 39/12 (2013.01); A61K 2039/55555 (2013.01); A61M 2037/0023 (2013.01); A61M 2037/0061 (2013.01)] 30 Claims
OG exemplary drawing
 
1. A dissolvable microneedle patch for delivery of a therapeutically active ingredient to skin comprising:
a plurality of microneedles and a removable substrate;
wherein the plurality of microneedles are attached to the removable substrate;
wherein the plurality of microneedles comprise a tapered tip that extends away from the removable substrate;
wherein the plurality of microneedles comprise a biodegradable polymer and a therapeutically active ingredient dispersed in the biodegradable polymer; and
wherein the therapeutically active ingredient is an immunogenic stimulator selected from the group consisting of Candida antigen, trichophyton antigen, and tuberculin; and
wherein the immunogenic stimulator is substantially free of glycerin.