US 12,005,157 B2
Isolation and co-transplantation of bone marrow mesenchymal stem cells with CD34+ hematopoietic stem/progenitor cells
Arun Sharma, Elmwood Park, IL (US); Natalie J. Fuller, Chicago, IL (US); Matthew I. Bury, Delkalb, IL (US); and Earl Y. Cheng, Elmhurst, IL (US)
Assigned to Northwestern University, Evanston, IL (US); and Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL (US)
Filed by Northwestern University, Evanston, IL (US); and ANN & ROBERT H. LURIE CHILDREN'S HOSPITAL OF CHICAGO, Chicago, IL (US)
Filed on Feb. 18, 2015, as Appl. No. 14/625,168.
Claims priority of provisional application 61/941,143, filed on Feb. 18, 2014.
Prior Publication US 2015/0231303 A1, Aug. 20, 2015
Int. Cl. A61L 27/38 (2006.01); A61L 27/54 (2006.01); A61L 27/58 (2006.01)
CPC A61L 27/3834 (2013.01) [A61L 27/54 (2013.01); A61L 27/58 (2013.01); A61L 2300/64 (2013.01); A61L 2430/22 (2013.01); A61L 2430/32 (2013.01)] 10 Claims
 
1. A system comprising:
(a) a synthetic elastomeric scaffold for supporting and transplantation of cells,
(b) a cell population of isolated mesenchymal stem cells (MSCs), wherein greater than 90% of the MSCs are CD29+, CD44+, CD73+, CD90+, CD105+, CD166+, CD14−, CD34−, CD45−, CD117−, and CD133−; and
(c) a cell population of hematopoietic stem/progenitor cells (HSPCs), wherein greater than 90% of the HSPCs are CD34+.