US 12,005,143 B2
Method for producing liposome and apparatus for producing liposome
Susumu Sugiyama, Kanagawa (JP); Naoki Yamada, Kanagawa (JP); Shigehisa Sugiyama, Kanagawa (JP); and Yohei Okubo, Minami-ashigara (JP)
Assigned to FUJIFILM Corporation, Tokyo (JP)
Filed by FUJIFILM Corporation, Tokyo (JP)
Filed on Jan. 11, 2018, as Appl. No. 15/868,160.
Application 15/868,160 is a division of application No. 15/625,391, filed on Jun. 16, 2017, granted, now 10,485,760.
Application 15/625,391 is a continuation of application No. PCT/JP2015/085455, filed on Dec. 18, 2015.
Claims priority of application No. 2014-257282 (JP), filed on Dec. 19, 2014.
Prior Publication US 2018/0133156 A1, May 17, 2018
Int. Cl. A61K 9/127 (2006.01); A61K 31/7068 (2006.01); B01F 23/40 (2022.01); B01F 23/41 (2022.01); B01F 25/21 (2022.01); B01F 25/50 (2022.01); B01J 13/04 (2006.01); B01J 13/08 (2006.01); B82Y 5/00 (2011.01); B82Y 40/00 (2011.01); B01F 101/22 (2022.01)
CPC A61K 9/1277 (2013.01) [A61K 9/127 (2013.01); A61K 9/1271 (2013.01); A61K 31/7068 (2013.01); B01F 23/40 (2022.01); B01F 23/41 (2022.01); B01F 25/21 (2022.01); B01F 25/50 (2022.01); B01J 13/04 (2013.01); B01J 13/08 (2013.01); B82Y 5/00 (2013.01); B82Y 40/00 (2013.01); B01F 2101/22 (2022.01)] 11 Claims
OG exemplary drawing
 
1. An apparatus for producing a liposome, comprising:
a first tank comprising an emulsifying apparatus;
a circulation path;
a second tank in the middle of the circulation path; and
a pump in the middle of the circulation path,
wherein the pump is configured to satisfy the formula “2X≥Y,” wherein X refers to the liquid feeding capacity (L/min) of the pump and Y refers to the capacity of circulation path (L),
wherein the first tank and the emulsifying apparatus are configured to stir and emulsify a liquid,
wherein the second tank is configured to separate and remove bubbles which are formed in the first tank,
wherein the ratio of the capacity of the circulation path to the total capacity of the first tank comprising the emulsifying apparatus and the circulation path is 0.4 or less, and said capacity of the circulation path refers to the capacity of the entire circulation path including the second tank,
wherein the pump is placed after the second tank and before the first tank.