US 12,005,128 B1
Near infrared small molecule probes for the detection of cellular senescence
Lina Cui, Gainesville, FL (US); Jun Liu, Gainesville, FL (US); Xiaowei Ma, Gainesville, FL (US); Ying Wang, Albuquerque, NM (US); and Philip Deenik, Albuquerque, NM (US)
Assigned to UNM Rainforest Innovations, Albuquerque, NM (US)
Filed by Lina Cui, Gainesville, FL (US); Jun Liu, Gainesville, FL (US); Xiaowei Ma, Gainesville, FL (US); Ying Wang, Albuquerque, NM (US); and Philip Deenik, Albuquerque, NM (US)
Filed on Apr. 2, 2020, as Appl. No. 16/838,907.
Claims priority of provisional application 62/828,242, filed on Apr. 2, 2019.
Int. Cl. A61K 49/00 (2006.01); G01N 33/58 (2006.01); C07D 491/052 (2006.01)
CPC A61K 49/0043 (2013.01) [A61K 49/0058 (2013.01); G01N 33/582 (2013.01); C07D 491/052 (2013.01); G01N 2458/00 (2013.01)] 3 Claims
 
1. A probe for visualization of senescent cells wherein the probe has the chemical structure:

OG Complex Work Unit Chemistry
where R is CHF2.