US 12,005,113 B2
Porcine epidemic diarrhea virus strains and immunogenic compositions therefrom
Jianqiang Zhang, Ames, IA (US); Qi Chen, Ames, IA (US); Phillip Gauger, Ames, IA (US); Darin Madson, Ames, IA (US); John Morgan Hardham, Parsippany, NJ (US); Meggan Bandrick, Parsippany, NJ (US); Jay Gregory Calvert, Parsippany, NJ (US); James Richard Thompson, Parsippany, NJ (US); Mira Ivanova Stoeva, Parsippany, NJ (US); and Walter Valdez, Parsippany, NJ (US)
Assigned to Zoetis Services LLC, Parsippany, NJ (US); and Iowa State University Research Foundation, Inc., Ames, IA (US)
Filed by IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC., Ames, IA (US); and ZOETIS SERVICES LLC, Parsippany, NJ (US)
Filed on Sep. 15, 2020, as Appl. No. 17/021,261.
Application 17/021,261 is a continuation of application No. 15/556,446, granted, now 11,058,763, previously published as PCT/US2016/019846, filed on Feb. 26, 2016.
Claims priority of provisional application 62/276,022, filed on Jan. 7, 2016.
Claims priority of provisional application 62/250,961, filed on Nov. 4, 2015.
Claims priority of provisional application 62/209,119, filed on Aug. 24, 2015.
Claims priority of provisional application 62/121,955, filed on Feb. 27, 2015.
Prior Publication US 2022/0088179 A1, Mar. 24, 2022
Int. Cl. A61K 39/215 (2006.01); A61K 39/12 (2006.01); C07K 14/165 (2006.01); A61K 39/00 (2006.01)
CPC A61K 39/215 (2013.01) [A61K 39/12 (2013.01); C07K 14/165 (2013.01); A61K 2039/51 (2013.01); A61K 2039/552 (2013.01); C12N 2770/20034 (2013.01)] 3 Claims
OG exemplary drawing
 
1. A vaccine composition comprising an isolated porcine epidemic diarrhea virus (PEDV) encoded by a DNA polynucleotide sequence that is SEQ ID NO: 36 or SEQ ID NO: 37, and a carrier,
wherein said composition is capable of protecting swine from challenge by both variant and prototype strains of PEDV and preventing or treating one or more symptoms associated with PEDV infection,
wherein achievement of protection is determined by an endpoint selected from the group consisting of prevention or control of any of the PEDV infection symptoms of dehydration, fever, diarrhea, vomiting, poor lactational performance, poor reproduction performance, mortality, and prevention or control of weight loss or failure to gain weight,
wherein said protected swine include any of sows, gilts, boars, hogs, and piglets and
wherein said vaccine is effective in a single dose program or in a two dose program, and wherein the minimum effective dose is about 104 log10TCID50/dose.