CPC A61K 39/215 (2013.01) [A61K 39/12 (2013.01); C07K 14/165 (2013.01); A61K 2039/51 (2013.01); A61K 2039/552 (2013.01); C12N 2770/20034 (2013.01)] | 3 Claims |
1. A vaccine composition comprising an isolated porcine epidemic diarrhea virus (PEDV) encoded by a DNA polynucleotide sequence that is SEQ ID NO: 36 or SEQ ID NO: 37, and a carrier,
wherein said composition is capable of protecting swine from challenge by both variant and prototype strains of PEDV and preventing or treating one or more symptoms associated with PEDV infection,
wherein achievement of protection is determined by an endpoint selected from the group consisting of prevention or control of any of the PEDV infection symptoms of dehydration, fever, diarrhea, vomiting, poor lactational performance, poor reproduction performance, mortality, and prevention or control of weight loss or failure to gain weight,
wherein said protected swine include any of sows, gilts, boars, hogs, and piglets and
wherein said vaccine is effective in a single dose program or in a two dose program, and wherein the minimum effective dose is about 104 log10TCID50/dose.
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