CPC A61K 35/17 (2013.01) [A61P 35/00 (2018.01); C07K 14/7051 (2013.01); C07K 16/2827 (2013.01)] | 16 Claims |
1. A recombinant chimeric antigen receptor (CAR) fusion protein comprising, in order:
an immune cell targeting domain, the immune cell targeting domain being a NK cell targeting domain, or a T cell targeting domain,
a cleavable peptide,
a membrane targeting domain, the membrane targeting domain being a peptide from interleukin-1 receptor type 1, 4F2 cell-surface antigen heavy chain, a linker for activation of T-cells family member 1, junctophilin-1, antilisterial bacteriocin subtilosin biosynthesis protein AlbG, calcitonin receptor, gamma-secretase subunit APH-1A, or adipnectin receptor protein 2,
an extracellular cancer targeting domain,
a transmembrane domain, and
an intracellular signaling domain.
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