CPC A61K 35/17 (2013.01) [C07K 14/7051 (2013.01); C07K 16/2803 (2013.01); C07K 16/2863 (2013.01); A61K 38/00 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01); C07K 2319/03 (2013.01)] | 28 Claims |
1. A method of treating a subject having acute myeloid leukemia (AML), wherein the method comprises delivering to the subject an autologous or an allogeneic T cell or Natural Killer (NK) cell comprising:
(a) an anti-FLT3 chimeric antigen receptor (CAR) comprising a FLT3-binding domain and an anti-CD33 CAR comprising a CD33-binding domain, or a bivalent CAR comprising a FLT3-binding domain and a CD33-binding domain,
wherein the FLT3-binding domain comprises a heavy chain variable domain (VH) comprising a CDR-H1 sequence comprising the amino acid sequence of SEQ ID NO: 81, a CDR-H2 sequence comprising the amino acid sequence of SEQ ID NO: 82, and a CDR-H3 sequence comprising the amino acid sequence of SEQ ID NO: 83 and a light chain variable domain (VL) comprising a CDR-L1 sequence comprising the amino acid sequence of SEQ ID NO: 84, a CDR-L2 sequence comprising the amino acid sequence of SEQ ID NO: 85, and a CDR-L3 sequence comprising the amino acid sequence of SEQ ID NO: 86, and
wherein the CD33-binding domain comprises VH comprising a CDR-H1 sequence comprising the amino acid sequence of SEQ ID NO: 123, a CDR-H2 sequence comprising the amino acid sequence of SEQ ID NO: 124, and a CDR-H3 sequence comprising the amino acid sequence of SEQ ID NO: 125 and a VL comprising a CDR-L1 sequence comprising the amino acid sequence of SEQ ID NO: 126, a CDR-L2 sequence comprising the amino acid sequence of SEQ ID NO: 127, and a CDR-L3 sequence comprising the amino acid sequence of SEQ ID NO: 128; and
(b) an inhibitory chimeric receptor comprising an extracellular antigen-binding domain that binds to EMCN.
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