CPC A61K 35/17 (2013.01) [A61K 38/1793 (2013.01); A61K 38/2013 (2013.01); C07K 14/55 (2013.01); C12N 5/0638 (2013.01); C12N 15/1034 (2013.01); A61K 2039/5156 (2013.01); A61K 2300/00 (2013.01); C12N 2740/10043 (2013.01)] | 29 Claims |
1. A nucleic acid encoding an engineered human IL-2 polypeptide, which comprises amino acid substitutions, numbered relative to reference SEQ ID NO:4:
E15S, E15T, E15Q, or E15H;
H16Q;
L19V or L19I;
D20T, D20S, D20L or D20M; and
M23L, M23S, M23V, M23A, or M23T;
and optionally comprises Q22K, Q22N, R81D, R81Y, T51I or a combination thereof.
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