US 12,005,050 B2
Methods for preventing or treating H. pylori infection
Zhenkun Ma, Suzhou (CN); Guozhu Geng, Suzhou (CN); Jing Chen, Suzhou (CN); Yu Liu, Suzhou (CN); Xiangyi Xu, Suzhou (CN); Changlin Ai, Suzhou (CN); Junlei Zhang, Suzhou (CN); Ting Song, Suzhou (CN); and Shuangshuang Zhao, Suzhou (CN)
Assigned to TENNOR THERAPEUTICS (SUZHOU) LIMITED, Suzhou (CN)
Filed by TENNOR THERAPEUTICS (SUZHOU) LIMITED, Suzhou (CN)
Filed on Aug. 1, 2023, as Appl. No. 18/363,006.
Claims priority of application No. PCT/CN2022/113421 (WO), filed on Aug. 18, 2022.
Prior Publication US 2024/0082229 A1, Mar. 14, 2024
Int. Cl. A61K 31/439 (2006.01); A61K 9/28 (2006.01); A61K 9/48 (2006.01); A61K 31/43 (2006.01); A61K 31/4439 (2006.01); A61P 31/04 (2006.01)
CPC A61K 31/439 (2013.01) [A61K 9/28 (2013.01); A61K 9/48 (2013.01); A61K 31/43 (2013.01); A61K 31/4439 (2013.01); A61P 31/04 (2018.01)] 14 Claims
OG exemplary drawing
 
1. A method for treating, ameliorating, and/or reversing a Helicobacter pylori (H. pylori) infection in a patient in need thereof, comprising administering to said patient:
an effective amount of compound I 4-Deoxy-3,4-(1H)-imidazo-(2,5-dihydro)rifamycin, or a pharmaceutically acceptable salt thereof; an effective amount of an additional antibiotic, and an effective amount of an acid blocker,
wherein said compound I is administered to said patient at a dose of about 400 mg to about 600 mg, twice per day (BID) or three times per day (TID),
wherein said compound I is a compound of Formula 2

OG Complex Work Unit Chemistry
wherein an effective amount of said acid blocker is at a dose of about 10 mg to about 20 mg, and said acid blocker is proton pump inhibitor (PPI); and,
wherein an effective amount of said additional antibiotic is twice per day (BID) or three times per day (TID), for 7-14 consecutive days; and said additional antibiotic is amoxicillin.