CPC A61K 31/215 (2013.01) [A61K 9/0034 (2013.01); A61K 9/0056 (2013.01); A61K 9/006 (2013.01); A61K 9/2027 (2013.01); A61K 9/2054 (2013.01); A61K 9/2059 (2013.01); A61K 31/5575 (2013.01); A61K 2121/00 (2013.01)] | 21 Claims |
1. A pharmaceutical tablet comprising misoprostol, or a pharmaceutically acceptable salt thereof, as the sole active ingredient; wherein the tablet has a content of 0.5-50 μg misoprostol, or an equivalent amount of a pharmaceutically acceptable salt thereof; and wherein the tablet further comprises:
i) 5-20 wt % crospovidone,
ii) 5-20 wt % of a cross-linked polymer of carboxymethyl cellulose or a crosslinked sodium carboxymethyl cellulose,
iii) 5-20 wt % starch,
iv) 30-85 wt % microcrystalline cellulose, and
v) 0.1-2 wt % flow agent, subject to the proviso that the total of ingredients i) through v) and the misoprostol, or a pharmaceutically acceptable salt thereof, does not exceed 100 wt %, and wherein the tablet is suitable for sublingual or oral administration and is an immediate release tablet.
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