|
1. A method of treating a human subject having a mitochondrial disorder or reducing severity of a symptom in a human subject having a mitochondrial disorder, said method comprising administering an effective amount of 12,13-dihydroxy-9Z-octadecenoic acid (12,13-diHOME), a stereoisomer, a geometric isomer, or a pharmaceutically acceptable salt thereof, to a subject having a mitochondrial disorder, wherein the mitochondrial disorder is selected from the group consisting of diabetes mellitus and deafness (DAD), Leber's hereditary optic neuropathy (LHON), Leigh syndrome, subacute sclerosing encephalopathy, neuropathy, ataxia, retinitis pigmentosa, and ptosis (NARP), myoneurogenic gastrointestinal encephalopathy (MNGIE), neuropathy, dementia, mitochondrial myopathy, myoclonic epilepsy with ragged red fibers (MERRF), progressive myoclonic epilepsy, mitochondrial myopathy, encephalomyopathy, lactic acidosis, stroke-like symptoms (MELAS), and mitochondrial neurogastrointestinal encephalomyopathy (MNGIE).
|