US 12,004,843 B2
Frequency domain diffuse optical spectroscopy device and optical detector calibration method
Roy A. Stillwell, Notre Dame, IN (US); Vincent James Kitsmiller, Notre Dame, IN (US); and Thomas D. O'Sullivan, Notre Dame, IN (US)
Assigned to UNIVERSITY OF NOTRE DAME DU LAC, Notre Dame, IN (US)
Appl. No. 17/045,070
Filed by UNIVERSITY OF NOTRE DAME DU LAC, Notre Dame, IN (US)
PCT Filed Apr. 5, 2019, PCT No. PCT/US2019/026088
§ 371(c)(1), (2) Date Oct. 2, 2020,
PCT Pub. No. WO2019/195749, PCT Pub. Date Oct. 10, 2019.
Claims priority of provisional application 62/653,364, filed on Apr. 5, 2018.
Prior Publication US 2021/0161389 A1, Jun. 3, 2021
Int. Cl. A61B 5/00 (2006.01)
CPC A61B 5/0075 (2013.01) [A61B 5/0013 (2013.01); A61B 5/7228 (2013.01); A61B 5/742 (2013.01); A61B 2560/0214 (2013.01); A61B 2560/0223 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A frequency domain diffuse optical spectroscopy device, comprising:
a housing sized to be handheld, wherein a light source is positioned at a first end of the housing;
a radio frequency signal generator;
a driver coupled to the radio frequency signal generator;
the light source coupled to the driver and configured to generate modulated light at a plurality of different wavelengths and a plurality of different modulation frequencies, the light source for emitting the modulated light at a sample;
a silicon photomultiplier configured to generate analog detection signals indicative of amplitude and phase of radio frequency modulation components of detected optical signals emanating from the sample in response to the modulated light;
an analog to digital conversion circuit (ADC) coupled to the radio frequency signal generator and coupled to the silicon photomultiplier, wherein the ADC is configured to generate digital sample values from the analog detection signals; and
an electronic processing circuit (EPC) coupled to the analog to digital conversion circuit and configured to
determine absorption values and scattering values based on the digital sample values,
determine concentration values based on the absorption values and the scattering values, and
determine an image stream based on the concentration values.