US 12,004,811 B2
Systems and methods for determining cross-linking distribution in a cornea and/or structural characteristics of a cornea
Desmond Christopher Adler, Bedford, MA (US); Jun A. Zhang, Lexington, MA (US); Mikhail Z. Smirnov, North Andover, MA (US); Marc D. Friedman, Needham, MA (US); David Usher, Waltham, MA (US); Grace Elizabeth Lytle, Boston, MA (US); and David C. Iannetta, Cambridge (MA)
Assigned to AVEDRO, INC., Waltham, MA (US)
Filed by Avedro, Inc., Waltham, MA (US)
Filed on Dec. 9, 2022, as Appl. No. 18/078,728.
Application 18/078,728 is a continuation of application No. 16/840,317, filed on Apr. 3, 2020, granted, now 11,529,050.
Application 16/840,317 is a continuation of application No. 15/868,457, filed on Jan. 11, 2018, granted, now 10,631,726, issued on Apr. 28, 2020.
Claims priority of provisional application 62/573,440, filed on Oct. 17, 2017.
Claims priority of provisional application 62/444,910, filed on Jan. 11, 2017.
Prior Publication US 2023/0103346 A1, Apr. 6, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 3/107 (2006.01); A61B 3/10 (2006.01); A61B 3/14 (2006.01); A61B 5/00 (2006.01); A61F 9/007 (2006.01); A61N 5/06 (2006.01); A61F 9/008 (2006.01)
CPC A61B 3/107 (2013.01) [A61B 3/10 (2013.01); A61B 3/14 (2013.01); A61B 5/0036 (2018.08); A61F 9/0079 (2013.01); A61N 5/062 (2013.01); A61B 5/0071 (2013.01); A61B 5/4848 (2013.01); A61F 2009/00872 (2013.01); A61N 2005/0661 (2013.01)] 17 Claims
OG exemplary drawing
 
1. A measurement system for a cornea, comprising:
a light source configured to emit light;
at least one optical element positioned to receive the light from the light source and configured to focus the light to an area of corneal tissue at a selected depth of the cornea, a light signal being generated at the area of corneal tissue in response to the light from the light source;
a detector positioned to capture the light signal transmitted by an aperture and configured to communicate information relating to a measurement of the light signal captured by the detector;
a scan mechanism configured to cause the at least one optical element to scan the cornea at a plurality of depths and to focus the light from the light source on a respective area of corneal tissue at each depth; and
a controller communicatively coupled to the detector and configured to receive the information from the detector and to determine, based on the information, a measurement of the light signal generated at the area of corneal tissue at the selected depth,
wherein the controller is configured to develop a three-dimensional profile of fluorescence emissions generated by the light, and wherein the controller is further configured to (1) determine that a treatment correction is required, and (2) cause the treatment correction.