US 12,326,449 B2
Fibrinogen biological material detection sensor including an erythrocyte membrane covered metal nanoparticle and fabricating method thereof
Jin Sung Park, Guri-si (KR); Seong Jae Jo, Seoul (KR); Joo Hyung Park, Jinju-si (KR); Won Seok Lee, Seoul (KR); Heon Jeong Lee, Seoul (KR); Dae Sung Yoon, Seoul (KR); Gyu Do Lee, Namyangju-si (KR); and In Su Kim, Seoul (KR)
Assigned to KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION, SEJONG CAMPUS, Sejong-si (KR)
Filed by KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION, SEJONG CAMPUS, Sejong-si (KR)
Filed on Apr. 19, 2021, as Appl. No. 17/233,859.
Application 17/233,859 is a continuation of application No. PCT/KR2019/013737, filed on Oct. 18, 2019.
Claims priority of application No. 10-2018-0124126 (KR), filed on Oct. 18, 2018; application No. 10-2019-0000054 (KR), filed on Jan. 2, 2019; and application No. 10-2019-0088035 (KR), filed on Jul. 22, 2019.
Prior Publication US 2021/0239693 A1, Aug. 5, 2021
Int. Cl. G01N 33/556 (2006.01); G01N 21/55 (2014.01); G01N 27/12 (2006.01); G01N 33/553 (2006.01); G01N 33/74 (2006.01); G01N 33/86 (2006.01)
CPC G01N 33/556 (2013.01) [G01N 27/127 (2013.01); G01N 33/553 (2013.01); G01N 33/743 (2013.01); G01N 33/86 (2013.01)] 7 Claims
OG exemplary drawing
 
1. A biomaterial detection sensor comprising:
a substrate; and
a detection probe including a metal nanoparticle deposited on the substrate, and an erythrocyte membrane conformally covering the metal nanoparticle,
wherein the detection probe sensitively reacts with fibrinogen,
wherein the biomaterial detection sensor is configured to linearly sense the fibrinogen in a concentration range of 0.001 to 10 mg/mL, and
wherein an amount of change in a surface plasmon resonance signal of the substrate that changes when the detection probe selectively reacts with the fibrinogen decreases linearly as the concentration of the fibrinogen decreases.
 
6. A method for fabricating a biomaterial detection sensor, comprising:
preparing a substrate and a metal nanoparticle;
depositing the metal nanoparticle on the substrate;
extracting an erythrocyte membrane from an erythrocyte; and
providing the erythrocyte membrane on the substrate where the metal nanoparticle is deposited, so as to form a detection probe including the metal nanoparticle on the substrate and the erythrocyte membrane conformally covering the metal nanoparticle,
wherein the detection probe sensitively reacts with fibrinogen,
wherein the biomaterial detection sensor is configured to linearly sense the fibrinogen in a concentration range of 0.001 to 10 mg/mL, and
wherein an amount of change in a surface plasmon resonance signal of the substrate that changes when the detection probe selectively reacts with the fibrinogen decreases linearly as the concentration of the fibrinogen decreases.