| CPC G01N 33/49 (2013.01) [A61B 5/14532 (2013.01); A61B 5/1473 (2013.01); A61B 5/1495 (2013.01); G16H 10/40 (2018.01); G16H 20/10 (2018.01); G16H 40/67 (2018.01); A61B 2560/0223 (2013.01); A61B 2560/0252 (2013.01); G16H 15/00 (2018.01); G16H 40/40 (2018.01); G16H 50/50 (2018.01)] | 11 Claims |

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1. A glucose monitoring system, comprising:
a glucose sensor including
a first portion configured to be positioned above a skin layer of the user, and
a second portion configured to be implanted transcutaneously below the skin layer of the user into a subcutaneous space and in contact with an interstitial fluid of the user and having
a working electrode, and
a reference electrode,
wherein the glucose sensor is configured to generate data signals associated with a glucose level of the interstitial fluid;
one or more processors; and
one or more memories storing a sensor code from manufacturing, wherein the memories are operatively coupled to the one or more processors for storing instructions which, when executed by the one or more processors, cause the one or more processors to:
retrieve a sensitivity and a predefined sensitivity range from the sensor code from manufacturing;
receive an unscheduled manual user calibration;
determine a composite sensitivity using a time based function based on the sensitivity, the predefined sensitivity range, and the unscheduled manual user calibration; and
determine a glucose level of the user based on the composite sensitivity and the data signals generated by the glucose sensor.
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