US 12,326,439 B2
Devices and methods for magnetic detection of tissue motion
Kevin Gray, Seattle, WA (US); and Jason Silver, Seattle, WA (US)
Assigned to Curi Bio, Inc., Seattle, WA (US)
Appl. No. 18/547,311
Filed by Curi Bio, Inc., Seattle, WA (US)
PCT Filed Feb. 9, 2023, PCT No. PCT/US2023/062255
§ 371(c)(1), (2) Date Aug. 21, 2023,
PCT Pub. No. WO2023/154775, PCT Pub. Date Aug. 17, 2023.
Claims priority of provisional application 63/308,474, filed on Feb. 9, 2022.
Prior Publication US 2024/0094186 A1, Mar. 21, 2024
Int. Cl. G01N 33/483 (2006.01); C12N 13/00 (2006.01); G01N 27/72 (2006.01)
CPC G01N 33/4833 (2013.01) [C12N 13/00 (2013.01); G01N 27/72 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A magnet localization method, comprising:
recording a magnetic field of each magnet of a plurality of magnets with a nearest magnetometer array of a plurality of magnetometer arrays, wherein the plurality of magnets are disposed within wells of a multi-well cartridge and each magnet is attached to a post of a plurality of posts, each post having a tissue of a plurality of tissues attached thereto, wherein the nearest magnetometer array for each magnet is a magnetometer array positioned adjacent to the well in which the magnet is disposed;
simulating, at one or more locations of each of the magnetometer arrays, a simulated magnetic field including directional components of a simulated magnet, wherein the simulated magnet has simulated positional information in theoretical space;
estimating positional information for each magnet based upon at least the recorded magnetic field of the magnet and iterating the simulated positional information of the simulated magnet; and
tracking movement of each tissue based upon the estimated positional information of the magnet attached to the post to which the tissue is attached.