US 12,326,427 B2
Preparative fluid chromatograph device
Takayuki Iriki, Kyoto (JP)
Assigned to SHIMADZU CORPORATION, Kyoto (JP)
Filed by SHIMADZU CORPORATION, Kyoto (JP)
Filed on Jan. 17, 2023, as Appl. No. 18/097,707.
Claims priority of application No. 2022-019551 (JP), filed on Feb. 10, 2022.
Prior Publication US 2023/0251232 A1, Aug. 10, 2023
Int. Cl. G01N 30/86 (2006.01); B01D 15/14 (2006.01); G01N 30/02 (2006.01); G01N 30/14 (2006.01); G01N 30/16 (2006.01)
CPC G01N 30/8631 (2013.01) [B01D 15/14 (2013.01); G01N 30/14 (2013.01); G01N 30/16 (2013.01); G01N 2030/027 (2013.01)] 5 Claims
OG exemplary drawing
 
1. A preparative fluid chromatograph device comprising:
a separation channel through which a mobile phase flows;
an injector configured to inject a sample into the mobile phase flowing through the separation channel;
a separation column that is provided downstream of the injector on the separation channel and for separating a plurality of components in the sample injected into the mobile phase by the injector from each other;
a detector that is provided downstream of the separation column on the separation channel and outputs a signal corresponding to concentration of the components eluted from the separation column;
a fraction collector that is provided downstream of the detector, and for separating an eluate eluted from the separation column into a plurality of parts and collecting each of the parts into a plurality of containers respectively; and
a controller configured to execute fractionation operation for each sample injected at one time into the mobile phase, wherein in the fractionation operation, the controller detects the components separated from each other in the separation column as peaks individually based on the signal output from the detector, and controls operation of the fraction collector such that the components detected as the peaks are collected in different containers,
wherein the controller is configured to set a reference number of the number of components in a sample injected into the mobile phase, to count number of components detected as the peaks for each sample injected into the mobile phase at a time by the injector, and to determine that the fractionation operation of the sample is completed when the number of components counted reaches the reference number and all components as many as the reference number are collected in the container.