US 12,326,396 B2
Optical transmission sample holder and analysis, particularly for hemoglobin
Stephen Y. Chou, Princeton, NJ (US); Wei Ding, East Windsor, NJ (US); Ji Qi, Skillman, NJ (US); Jun Tian, Belle Mead, NJ (US); and Wu Chou, Basking Ridge, NJ (US)
Assigned to Essenlix Corporation, Monmouth Junction, NJ (US)
Filed by Essenlix Corporation, Monmouth Junction, NJ (US)
Filed on Nov. 9, 2023, as Appl. No. 18/505,118.
Application 18/505,118 is a continuation of application No. 17/858,931, filed on Jul. 6, 2022, granted, now 11,846,582.
Application 17/858,931 is a continuation of application No. 17/175,585, filed on Feb. 12, 2021, granted, now 11,415,504, issued on Aug. 16, 2022.
Application 17/858,931 is a continuation of application No. 16/771,502, granted, now 10,955,334, issued on Mar. 23, 2021, previously published as PCT/US2018/065874, filed on Dec. 14, 2018.
Claims priority of provisional application 62/598,899, filed on Dec. 14, 2017.
Prior Publication US 2024/0175801 A1, May 30, 2024
Int. Cl. G01N 21/03 (2006.01); A61K 31/7088 (2006.01); A61K 45/06 (2006.01); A61K 47/54 (2017.01); A61P 31/04 (2006.01); C12N 15/113 (2010.01); G01N 1/28 (2006.01); G01N 21/25 (2006.01); G01N 21/64 (2006.01); G01N 33/49 (2006.01)
CPC G01N 21/0303 (2013.01) [A61K 31/7088 (2013.01); A61K 45/06 (2013.01); A61K 47/554 (2017.08); A61P 31/04 (2018.01); C12N 15/113 (2013.01); C12N 15/1137 (2013.01); G01N 1/2813 (2013.01); G01N 21/25 (2013.01); G01N 21/6458 (2013.01); G01N 33/49 (2013.01); C12N 2310/127 (2013.01); C12N 2310/3515 (2013.01); C12Y 305/02006 (2013.01); G01N 2021/035 (2013.01); G01N 2021/6439 (2013.01); G01N 2201/0221 (2013.01)] 11 Claims
OG exemplary drawing
 
1. A device for an optical transmission analysis of sample by a light, comprising:
a first plate, a second plate, and a light-guiding spacer (LGS), wherein:
the first plate and the second plate are movable relative to each other to form different configurations, including an open configuration and a closed configuration;
in the closed configuration, the first and second plates are configured to compress a sample into a layer between the first and second plates, and each of the first and second plates has a sample contact area contacting the sample;
in the closed configuration, the light-guiding spacer is sandwiched between the first and second plates and in direct contact with the first and second plates to form a sample region and a reference region;
wherein the sample region is a region where the light is capable of transmitting through the first plate, the sample, and the second plate, wherein the sample region does not have the LGS; and
the reference region is a region where the light is capable of transmitting through the first plate, the light-guiding spacer, and the second plate, without going through the sample; and
wherein the lateral cross-section of the LGS is larger than a wavelength of the light.