US 12,326,200 B2
Centrifugal cassette with molded insertable valves
Randy Peery, Lakewood, CO (US); James Ladtkow, Broomfield, CO (US); Jesse Janzen, Golden, CO (US); Andrew Gloor, Lakewood, CO (US); and Kevin Klimek, Denver, CO (US)
Assigned to Terumo BCT, Inc., Lakewood, CO (US)
Appl. No. 17/430,434
Filed by Terumo BCT, Inc., Lakewood, CO (US)
PCT Filed Feb. 26, 2020, PCT No. PCT/US2020/019914
§ 371(c)(1), (2) Date Aug. 12, 2021,
PCT Pub. No. WO2020/180563, PCT Pub. Date Sep. 10, 2020.
Claims priority of provisional application 62/812,666, filed on Mar. 1, 2019.
Prior Publication US 2022/0112967 A1, Apr. 14, 2022
Int. Cl. F16K 99/00 (2006.01); A61M 1/36 (2006.01); B04B 5/04 (2006.01); B29C 45/00 (2006.01); B29K 23/00 (2006.01); B29L 31/00 (2006.01); G01N 35/00 (2006.01)
CPC F16K 99/0011 (2013.01) [A61M 1/36226 (2022.05); A61M 1/362262 (2022.05); A61M 1/362265 (2022.05); B04B 5/0442 (2013.01); B29C 45/0053 (2013.01); B29K 2023/083 (2013.01); B29L 2031/7506 (2013.01); F16K 99/0036 (2013.01); F16K 2099/0078 (2013.01); F16K 2099/0084 (2013.01); G01N 2035/00495 (2013.01)] 22 Claims
OG exemplary drawing
 
7. A centrifuge cassette assembly for separating a fluid, the cassette assembly comprising:
a first chamber;
a second chamber;
a fluidic channel creating a fluid connection between the first chamber and the second chamber;
a molded insertion valve configured to control the flow of fluid in the fluidic channel; and
a heating element for actuating the molded insertion valve,
wherein the molded insertion valve includes either a normally closed valve (NCV) or a normally open valve (NOV),
wherein the normally closed valve (NCV) includes a first valve base including at least one first interference seal member; a pair of valve seal posts; and an elongated valve rib that extends between and connects the pair of valve seal posts, and is configured to seal the fluidic channel; wherein the at least one first interference seal member is configured to cooperate with at least one interference seal member of a valve seat; and
wherein the normally open valve (NOV) includes a second valve base including a first truncated cone section having a first base connected to a second base of a second connected cone section, the connection between the first base and the second base of the first and second truncated cone sections defining a second interference seal member; and a lumen, wherein the second interference seal member is configured to cooperate with the at least one interference seal member of the valve seat.