US 12,325,767 B2
Degradable microsphere and use thereof
Jianbin Wang, Beijing (CN); Hongwei Wang, Beijing (CN); Junlong Yin, Beijing (CN); and Meng Tian, Beijing (CN)
Assigned to Tsinghua University, Beijing (CN)
Appl. No. 17/251,082
Filed by Tsinghua University, Beijing (CN)
PCT Filed May 31, 2019, PCT No. PCT/CN2019/089508
§ 371(c)(1), (2) Date Dec. 10, 2020,
PCT Pub. No. WO2019/237952, PCT Pub. Date Dec. 19, 2019.
Claims priority of application No. 201810608246.5 (CN), filed on Jun. 13, 2018.
Prior Publication US 2021/0255074 A1, Aug. 19, 2021
Int. Cl. C08F 220/56 (2006.01); B01D 15/38 (2006.01); B01D 21/26 (2006.01); C07K 1/14 (2006.01); C07K 1/22 (2006.01); C07K 1/36 (2006.01); C08J 3/075 (2006.01); G01N 1/40 (2006.01); G01N 21/64 (2006.01); G01N 23/04 (2018.01); G01N 23/06 (2018.01); G01N 33/68 (2006.01); H01J 49/00 (2006.01)
CPC C08F 220/56 (2013.01) [B01D 15/3809 (2013.01); B01D 21/262 (2013.01); C07K 1/145 (2013.01); C07K 1/22 (2013.01); C07K 1/36 (2013.01); C08J 3/075 (2013.01); G01N 1/4044 (2013.01); G01N 1/405 (2013.01); G01N 21/6458 (2013.01); G01N 23/04 (2013.01); G01N 23/06 (2013.01); G01N 33/6848 (2013.01); H01J 49/0031 (2013.01); C08J 2333/26 (2013.01); G01N 2223/04 (2013.01); G01N 2223/418 (2013.01)] 16 Claims
 
1. A degradable microbead comprising a polymer molecule crosslinked by a crosslinking agent, wherein the polymer molecule and/or the crosslinking agent comprises a sensitive chemical bond, wherein the sensitive chemical bond is cleavable through a chemical and/or light treatment, thereby resulting in the degradation of the degradable microbead, wherein
(i) the polymer molecule is selected from the group consisting of polyacrylic acid-based compounds, polyacrylate-based compounds, polyacrylamide-based compounds, polyvinyl alcohol-based compounds, and polyethylene glycol-based compounds, and the crosslinking agent is selected from o-nitrophenylethyl alcohol-based compounds or o-nitrobenzyl alcohol-based compounds, wherein the sensitive chemical bond is provided by o-nitrophenylethyl alcohol-based compounds or o-nitrobenzyl alcohol-based compounds; or
(ii) the polymer molecule is a copolymer of acrylamide and cystamine acrylamide, and the crosslinking agent is cystamine bisacrylamide, wherein the sensitive chemical bond is provided by cystamine-based compounds.