US 12,325,714 B2
Compositions of thienopyrimidine derivatives
Kazuhiro Miwa, Osaka (JP)
Assigned to Takeda Pharmaceutical Company Limited, Osaka (JP)
Filed by Takeda Pharmaceutical Company Limited, Osaka (JP)
Filed on Oct. 25, 2024, as Appl. No. 18/927,346.
Application 16/116,804 is a division of application No. 15/481,505, filed on Apr. 7, 2017, granted, now 10,150,778, issued on Dec. 11, 2018.
Application 15/481,505 is a division of application No. 14/432,188, granted, now 9,758,528, issued on Sep. 12, 2017, previously published as PCT/JP2013/077013, filed on Sep. 27, 2013.
Application 18/927,346 is a continuation of application No. 18/121,886, filed on Mar. 15, 2023, granted, now 12,180,224.
Application 18/121,886 is a continuation of application No. 17/694,635, filed on Mar. 14, 2022, granted, now 11,795,178, issued on Oct. 24, 2023.
Application 17/694,635 is a continuation of application No. 17/349,584, filed on Jun. 16, 2021, granted, now 11,731,983, issued on Aug. 22, 2023.
Application 17/349,584 is a continuation of application No. 16/710,390, filed on Dec. 11, 2019, granted, now 11,053,257, issued on Jul. 6, 2021.
Application 16/710,390 is a continuation of application No. 16/116,804, filed on Aug. 29, 2018, granted, now 10,544,160, issued on Jan. 28, 2020.
Claims priority of application No. 2012/217679 (JP), filed on Sep. 28, 2012.
Prior Publication US 2025/0051353 A1, Feb. 13, 2025
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 495/04 (2006.01); C07D 333/38 (2006.01); C07D 409/12 (2006.01)
CPC C07D 495/04 (2013.01) [C07D 333/38 (2013.01); C07D 409/12 (2013.01)] 30 Claims
 
1. A solid mixture comprising 1-{4-[1-(2,6-difluorobenzyl)-5-dimethylaminomethyl-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno [2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea, or a salt or solvate thereof, and 1-{4-[1-(2,6-difluorobenzyl)-5-dimethylaminomethyl-2,4-dioxo-3-(6-oxo-1,6-dihydropyridazin-3-yl)-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea.