US 12,325,703 B2
Fused ring compound as FGFR and VEGFR dual inhibitor
Zhengxia Chen, Shanghai (CN); Haizhong Tan, Shanghai (CN); Yang Zhang, Shanghai (CN); Jian Li, Shanghai (CN); and Shuhui Chen, Shanghai (CN)
Assigned to CGeneTech (Suzhou, China) CO., Ltd., Jiangsu (CN)
Appl. No. 17/596,531
Filed by CGENETECH (SUZHOU, CHINA) CO., LTD., Jiangsu (CN)
PCT Filed Jun. 12, 2020, PCT No. PCT/CN2020/095864
§ 371(c)(1), (2) Date Dec. 13, 2021,
PCT Pub. No. WO2020/249096, PCT Pub. Date Dec. 17, 2020.
Claims priority of application No. 201910516134.1 (CN), filed on Jun. 14, 2019; application No. 201911044514.6 (CN), filed on Oct. 30, 2019; and application No. 202010033842.2 (CN), filed on Jan. 13, 2020.
Prior Publication US 2022/0315581 A1, Oct. 6, 2022
Int. Cl. C07D 471/04 (2006.01); A61P 35/00 (2006.01); C07D 487/04 (2006.01)
CPC C07D 471/04 (2013.01) [A61P 35/00 (2018.01); C07D 487/04 (2013.01)] 17 Claims
 
1. A compound represented by formula (III) or a pharmaceutically acceptable salt thereof,

OG Complex Work Unit Chemistry
wherein,
T, T2 and T3 are each independently selected from N, and CH;
R1 is selected from H, C1-3 alkyl, tetrahydropyranyl, piperidinyl,

OG Complex Work Unit Chemistry
 wherein the C1-3 alkyl, tetrahydropyranyl, piperidinyl,

OG Complex Work Unit Chemistry
 are optionally substituted with 1, 2 or 3 Ra, and further wherein custom character is used to denote a point of attachment;
R2 and R3 are each independently selected from H, F, Cl, Br, I, OH, and NH2;
R4 is selected from H, C1-3 alkyl, C1-3 alkoxy, C3-5 cycloalkyl, —CH2-1,3-dioxolanyl, and pyrrolidinyl, wherein the C1-3 alkyl, C1-3 alkoxy, C3-5 cycloalkyl, —CH2-1,3-dioxolanyl, and pyrrolidinyl are optionally substituted with 1, 2 or 3 Rb;
L is selected from —N(R5)C(═O)—, —N(R5)S(═O)2—, —N(R5)C(═O)N(R6)—, and —NR5—;
R5 and R6 are each independently selected from H, and C1-3 alkyl;
ring A is selected from phenyl, and pyridyl;
ring B is selected from cyclopropyl, morpholinyl, piperazinyl, tetrahydropyranyl, pyrazolyl, imidazolyl, and triazolyl;
Ra and Rb are each independently selected from H, F, Cl, Br, I, OH, NH2, CN, CH3, N(CH3)2, —S(═O)2CH3, and benzyl.