| CPC C07D 403/14 (2013.01) [A61P 31/04 (2018.01); C07D 239/54 (2013.01); C07D 401/06 (2013.01); C07D 401/10 (2013.01); C07D 401/12 (2013.01); C07D 403/10 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/12 (2013.01); C07D 413/14 (2013.01); C07D 487/04 (2013.01); C07D 491/048 (2013.01); C07D 491/107 (2013.01)] | 18 Claims |
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1. A compound having the structure of Formula (II):
 or a pharmaceutically acceptable salt, or solvate thereof, wherein,
n is 0-4;
m is 0-4;
A1 is OH or SH;
A2 is O or S;
R1 and R2 are each independently H or optionally substituted alkyl;
or R1 and R2 are taken together with the carbon to which they are attached to form ═C(R11)2, ═NR11, ═O, or ═S;
or R1 and R2 are taken together with the carbon to which they are attached to form an optionally substituted 3- to 6-membered carbocyclyl or optionally substituted 4- to 7-membered heterocyclyl containing 1 or 2 heteroatoms selected from O, N, and S;
R3 is optionally substituted alkyl, optionally substituted carbocyclyl, optionally substituted carbocyclylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted heteroaralkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted (C0-C4 alkylene)-COR11, optionally substituted (C0-C4 alkylene)-CO2R11, optionally substituted (C0-C4 alkylene)-CON(R11)2, optionally substituted (C0-C4 alkylene)-CN, optionally substituted (C0-C4 alkylene)-OR11, optionally substituted (C0-C4 alkylene)-N(R11)2, optionally substituted (C0-C4 alkylene)-N(R12)—COR11, optionally substituted (C0-C4 alkylene)-N(R12)—CO2R11, optionally substituted (C0-C4 alkylene)-N(R12)—CON(R11)2, optionally substituted (C0-C4 alkylene)-N(R12)—SO2N(R11)2, optionally substituted (C0-C4 alkylene)-O—SO2N(R11)2, optionally substituted (C0-C4 alkylene)-N(R11)—PO (optionally substituted C1-C4 alkyl)2, optionally substituted (C0-C4 alkylene)-SO2R11, optionally substituted (C0-C4 alkylene)-O—SO2R11, optionally substituted (C0-C4 alkylene)-N(R12)—SO2R11, optionally substituted (C0-C4 alkylene)-C(═N—OR11)(R11), or optionally substituted (C0-C4 alkylene)-OP(═O)(OR11)2;
R4 is H or optionally substituted alkyl;
or R3 and R4 are taken together with the carbon to which they are attached to form ═C(R11)2, ═NR11, ═O, or ═S;
or R3 and R4 are taken together with the carbon to which they are attached to form an optionally substituted 3- to 6-membered carbocyclyl or optionally substituted 4- to 7-membered heterocyclyl containing 1 or 2 heteroatoms selected from O, N, and S;
R5 is H, halogen, optionally substituted alkyl, hydroxyl, alkoxyl, cyano, amino, or nitro;
each X and Y is independently H, optionally substituted alkyl, halo, fluoroalkyl, cyano, nitro, —N(R13)2, or —OR13;
or R3 and one X are taken together with the intervening atoms to form an optionally substituted 5- to 7-membered carbocyclyl or optionally substituted 5- to 7-membered heterocyclyl containing 1 or 2 heteroatoms selected from O, N, and S;
Z is H, halo, nitro, or -L-G;
L is a bond or optionally substituted C1-C4 alkylene;
G is optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted aryl, optionally substituted heteroaryl, —CN, —N(R13)2, —OR13, —COR13, —CO2R13, —CON(R13)2, —N(R14)—COR13, —SO2R13—, —SO2N(R13)2, —N(R14)—SO2R13, —N(R14)—CON(R13)2, —N(R14)—CO2R13, —O—CON(R13)2—, —N(R14)—SO2N(R13)2, —O—SO2N(R13)2, —N(R14)—SO2—OR13, or —C(═N—OR14)(R13);
each R11 is independently H, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted carbocyclylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, or optionally substituted heteroarylalkyl;
or two R11 on the same nitrogen atom are taken together with the nitrogen to which they are attached to form an optionally substituted N-heterocyclyl;
each R12 is independently H, optionally substituted alkyl, optionally substituted carbocyclyl, optionally substituted carbocyclylalkyl, optionally substituted heterocyclyl, or optionally substituted heterocyclylalkyl;
each R13 is H, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted carbocyclylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, or optionally substituted heteroarylalkyl; and
each R14 is independently H, optionally substituted alkyl, optionally substituted carbocyclyl, optionally substituted carbocyclylalkyl, optionally substituted heterocyclyl, or optionally substituted heterocyclylalkyl;
wherein
each carbocyclyl is a stable non-aromatic monocyclic, fused polycyclic, or bridged polycyclic hydrocarbon ring comprising from three to ten carbon atoms;
each heterocyclyl is a stable 3- to 18-membered non-aromatic monocyclic, fused bicyclic, bridged bicyclic, or spirocyclic bicyclic ring system comprising from two to twelve carbon atoms and from one to six heteroatoms selected from nitrogen, oxygen, and sulfur which is optionally oxidized; and
each heterocyclylalkyl is a —Rc— heterocyclyl, where Rc is a C1-C8 alkylene.
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