US 12,325,697 B2
CBL-B modulators and uses thereof
Silvana Marcel Leit De Moradei, Burlington, MA (US); Angela V. West, Franklin, MA (US); Thomas Baker, Nottingham (GB); Jokin Carrillo Arregui, Nottingham (GB); Diana Castagna, Nottingham (GB); Jeremy Robert Greenwood, Brooklyn, NY (US); Salma Rafi, Lexington, MA (US); Fiona McRobb, New York, NY (US); and Yan Zhang, Jersey City, NJ (US)
Assigned to Nimbus Clio, Inc., Boston, MA (US)
Filed by Nimbus Clio, Inc., Cambridge, MA (US)
Filed on Apr. 8, 2022, as Appl. No. 17/658,587.
Claims priority of provisional application 63/264,940, filed on Dec. 3, 2021.
Claims priority of provisional application 63/173,121, filed on Apr. 9, 2021.
Prior Publication US 2023/0086064 A1, Mar. 23, 2023
Int. Cl. C07D 403/10 (2006.01); A61P 35/02 (2006.01); C07D 209/44 (2006.01); C07D 249/08 (2006.01); C07D 401/14 (2006.01); C07D 403/12 (2006.01); C07D 405/14 (2006.01); C07D 413/10 (2006.01); C07D 413/14 (2006.01); C07D 471/04 (2006.01); C07D 491/048 (2006.01); C07D 491/107 (2006.01); C07D 498/08 (2006.01); C07D 498/10 (2006.01); C07F 5/02 (2006.01)
CPC C07D 403/10 (2013.01) [A61P 35/02 (2018.01); C07D 209/44 (2013.01); C07D 249/08 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 405/14 (2013.01); C07D 413/10 (2013.01); C07D 413/14 (2013.01); C07D 471/04 (2013.01); C07D 491/048 (2013.01); C07D 491/107 (2013.01); C07D 498/08 (2013.01); C07D 498/10 (2013.01); C07F 5/022 (2013.01)] 8 Claims
 
1. A compound of formula I:

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or a pharmaceutically acceptable salt thereof, wherein:
Ring A together with its R1 substituents is

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Ring B together with its R2 substituents is

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Ring C together with its R3 substituents is

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each R8 is independently hydrogen, fluoro, chloro, bromo, methyl, —CF3, —OH, or —OMe;
-L-R9 is —COMe,

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q is 0, 1, or 2; and
t is 0 or 1.