US 12,325,691 B2
Compounds and methods for treating cancer, neurological disorders, ethanol withdrawal, anxiety, depression, and neuropathic pain
Stephen F. Martin, Austin, TX (US); James J. Sahn, Austin, TX (US); Luisa Scott, Austin, TX (US); and Jonathan Thomas Pierce-Shimomura, Round Rock, TX (US)
Assigned to BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Austin, TX (US)
Filed by BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Austin, TX (US)
Filed on Oct. 16, 2019, as Appl. No. 16/654,454.
Application 16/654,454 is a continuation of application No. 14/978,204, filed on Dec. 22, 2015, granted, now 10,450,275.
Application 14/978,204 is a continuation of application No. PCT/US2014/046730, filed on Jul. 15, 2014.
Claims priority of provisional application 61/846,234, filed on Jul. 15, 2013.
Prior Publication US 2020/0115345 A1, Apr. 16, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 221/24 (2006.01); A61K 31/496 (2006.01); C07D 223/16 (2006.01); C07D 401/06 (2006.01); C07D 403/04 (2006.01); C07D 403/06 (2006.01); C07D 405/04 (2006.01); C07D 405/06 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01)
CPC C07D 221/24 (2013.01) [C07D 223/16 (2013.01); C07D 401/06 (2013.01); C07D 403/04 (2013.01); C07D 403/06 (2013.01); C07D 405/04 (2013.01); C07D 405/06 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); A61K 31/496 (2013.01)] 8 Claims
OG exemplary drawing
 
1. A compound having the formula:

OG Complex Work Unit Chemistry
wherein:
R1 is substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl;
R2 is —C(O)R4, —S(O)n2R4, heteroatom-substituted alkyl, heteroatom-substituted or unsubstituted heteroalkyl, or heteroatom-substituted cycloalkyl, heteroatom-substituted or unsubstituted heterocycloalkyl;
n2 is 1 or 2;
n is 1 or 2; and
R4 is heteroatom-substituted alkyl, heteroatom-substituted or unsubstituted heteroalkyl, heteroatom-substituted cycloalkyl, or heteroatom-substituted or unsubstituted heterocycloalkyl, wherein
the term “heteroatom-substituted” means that one or more hydrogen atoms on the R2 and R4 chemical groups have been replaced with one or more of the following groups: halogen, —CF3, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO2Cl, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —NHC(O)NH2, —NHSO2H, —NHC(O)H, —NHC(O)—OH, —NHOH, —OCF3, or —OCHF2;
provided that the compound is not a compound of the formula:

OG Complex Work Unit Chemistry