US 12,325,028 B1
Flowcell cartridge with floating bracket
David Elliott Kaplan, Carlsbad, CA (US); Anthony John de Ruyter, San Diego, CA (US); Richard Alan Kelley, San Diego, CA (US); and Ashish Kumar, San Diego, CA (US)
Assigned to Illumina, Inc., San Diego, CA (US)
Filed by Illumina, Inc., San Diego, CA (US)
Filed on Feb. 11, 2025, as Appl. No. 19/051,076.
Application 19/051,076 is a division of application No. 18/827,174, filed on Sep. 6, 2024, granted, now 12,251,702.
Application 18/167,836 is a division of application No. 16/777,881, filed on Jan. 30, 2020, granted, now 11,577,253, issued on Feb. 14, 2023.
Application 16/777,881 is a division of application No. 16/436,485, filed on Jun. 10, 2019, granted, now 10,549,282, issued on Feb. 4, 2020.
Application 18/827,174 is a continuation of application No. 18/167,836, filed on Feb. 11, 2023, granted, now 12,097,502, issued on Sep. 24, 2024.
Application 16/436,485 is a continuation of application No. 15/841,109, filed on Dec. 13, 2017, granted, now 10,357,775, issued on Jul. 23, 2019.
Claims priority of provisional application 62/441,927, filed on Jan. 3, 2017.
Claims priority of application No. 1704769 (GB), filed on Mar. 24, 2017.
Int. Cl. B01L 9/00 (2006.01); B01L 3/00 (2006.01)
CPC B01L 9/527 (2013.01) [B01L 3/502715 (2013.01); B01L 2200/025 (2013.01); B01L 2200/027 (2013.01); B01L 2200/04 (2013.01); B01L 2200/0689 (2013.01); B01L 2300/041 (2013.01); B01L 2300/0609 (2013.01); B01L 2300/0809 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/0822 (2013.01); B01L 2300/0877 (2013.01)] 8 Claims
OG exemplary drawing
 
1. A chemical or biological analysis system comprising:
a microfluidic cartridge that includes:
a frame;
a microfluidic plate positioned within the frame, wherein the microfluidic plate floats relative to the frame, the microfluidic plate comprising a first side, a first edge, and a plurality of first fluidic ports located in the first side; and
a bracket positioned within the frame, wherein the bracket floats relative to the microfluidic plate and the frame, the bracket comprising a gasket and a plurality of alignment holes, wherein the frame includes a plurality of apertures proximate the first edge of the microfluidic plate; and
a sequencer with a receiver configured to receive the microfluidic cartridge, the receiver including:
a chuck;
a plurality of analysis device ports;
a first plurality of indexing features corresponding to the plurality of alignment holes; and
a second plurality of indexing features corresponding to the plurality of apertures, wherein:
the first plurality of indexing features and the plurality of alignment holes are configured to align the plurality of analysis device ports and the gasket, and
the second plurality of indexing features are configured to engage the microfluidic plate to align the plurality of first fluidic ports and the gasket.