US 12,324,933 B2
Device for ultra-high dose rate radiation treatment
Jean Francois Marie Bourhis, Corseaux (CH); Marie-Catherine Sophine Vozenin, Etoy (CH); Jean-Francois Germond, Chez-le-Bart (CH); Walter Wuensch, Onex (CH); Steinar Stapnes, Versoix (CH); and Alexej Grudiev, Duillier (CH)
Assigned to CERN—EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH, Geneva (CH); and CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS (C.H.U.V.), Lausanne (CH)
Appl. No. 17/761,800
Filed by CERN—EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH, Geneva (CH); and CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS (C.H.U.V.), Lausanne (CH)
PCT Filed Sep. 24, 2020, PCT No. PCT/EP2020/076662
§ 371(c)(1), (2) Date Mar. 18, 2022,
PCT Pub. No. WO2021/058624, PCT Pub. Date Apr. 1, 2021.
Claims priority of application No. 19199864 (EP), filed on Sep. 26, 2019.
Prior Publication US 2022/0387824 A1, Dec. 8, 2022
Int. Cl. A61N 5/10 (2006.01)
CPC A61N 5/1077 (2013.01) [A61N 2005/1087 (2013.01); A61N 2005/1089 (2013.01)] 17 Claims
OG exemplary drawing
 
1. A device for providing an ultra-high dose rate radiation treatment to a patient, the device comprising:
a radiation source arranged to provide a radiation beam;
a single linear accelerator arranged to accelerate said radiation beam until reaching a predetermined energy; and
a beam delivery module arranged to deliver the accelerated radiation beam from said single linear accelerator toward the patient to treat a target volume with a radiation dose, wherein:
the device is arranged to generate the accelerated radiation beam having the predetermined energy between about 50 MeV and about 250 MeV, and to deliver an ultra-high dose rate radiation dose of at least about 10 Gy, during an overall time less than about 200 ms,
the device is arranged for generating a radiation field for treating the target volume of at least about 30 cm3 with said ultra-high dose rate radiation dose, and/or treating a target volume located at least about 5 cm deep in the tissue of the patient with said ultra-high dose rate radiation dose, and
the single linear accelerator is arranged to generate a single accelerated beam comprising multiple trains of particle bunches, the beam delivery module is arranged to separate the single accelerated radiation beam into a plurality of accelerated beam lines separated by a determined angle, and subsequently focus each of said beam lines toward the patient to arrive simultaneously on the target volume, and each beam line corresponds to multiple trains of particle bunches,
wherein the beam delivery module is arranged to separate the accelerated radiation beam into a plurality of accelerated beam lines with a radiation dose of between 7 Gy and 20 Gy per beam delivered during said overall time, and
wherein the beam delivery module includes a magnetic spectrometer.