US 12,324,903 B2
Botulinum toxin prefilled plastic syringe
Markus Vogt, Frankfurt am Main (DE)
Assigned to Merz Pharma GmbH & Co. KGaA, Frankfurt am Main (DE)
Filed by Merz Pharma Gmbh & Co. KGaA, Frankfurt am Main (DE)
Filed on Nov. 23, 2021, as Appl. No. 17/534,229.
Application 17/534,229 is a continuation of application No. 16/459,382, filed on Jul. 1, 2019, granted, now 11,219,717.
Application 16/459,382 is a continuation of application No. 15/547,941, granted, now 10,406,290, issued on Sep. 10, 2019, previously published as PCT/EP2015/002600, filed on Dec. 22, 2015.
Claims priority of application No. 15000310 (EP), filed on Feb. 3, 2015.
Prior Publication US 2022/0080127 A1, Mar. 17, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61M 5/31 (2006.01); A61K 8/64 (2006.01); A61K 8/66 (2006.01); A61K 9/00 (2006.01); A61K 38/48 (2006.01); A61K 47/26 (2006.01); A61M 5/24 (2006.01); A61M 5/315 (2006.01); A61M 5/32 (2006.01); A61Q 19/08 (2006.01)
CPC A61M 5/3129 (2013.01) [A61K 8/64 (2013.01); A61K 8/66 (2013.01); A61K 9/0019 (2013.01); A61K 38/4893 (2013.01); A61K 47/26 (2013.01); A61M 5/24 (2013.01); A61M 5/31505 (2013.01); A61M 5/31513 (2013.01); A61M 5/3202 (2013.01); A61Q 19/08 (2013.01); C12Y 304/24069 (2013.01); A61K 2800/87 (2013.01); A61K 2800/91 (2013.01); A61M 2005/3131 (2013.01); A61M 2205/0216 (2013.01); A61M 2205/0222 (2013.01); A61M 2205/0238 (2013.01); Y02A 50/30 (2018.01)] 12 Claims
 
1. A prefilled plastic container comprising an aqueous botulinum toxin formulation, wherein the toxin activity is not reduced by more than 25%, relative to the initial toxin activity, upon storage of the prefilled container for 12 months at 5° C. or 3 months at 25° C.