	US 12,324,893 B2
	Triptan microporation delivery system
Hirotoshi Adachi, San Diego, CA (US); Shohei Horie, San Diego, CA (US); Akinori Hanatani, San Diego, CA (US); Masato Nishimura, Osaka (JP); Yuki Yamada, San Diego, CA (US); and Joe Hua, Rosemead, CA (US)
Assigned to PassPort Technologies, Inc., San Diego, CA (US)
Filed by PassPort Technologies, Inc., San Diego, CA (US)
Filed on May 1, 2023, as Appl. No. 18/310,041.
Application 18/310,041 is a continuation of application No. 16/911,181, filed on Jun. 24, 2020, granted, now 11,638,809.
Claims priority of provisional application 62/868,697, filed on Jun. 28, 2019.
Prior Publication US 2023/0264004 A1, Aug. 24, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/4045 (2006.01); A61K 9/70 (2006.01); A61K 31/4196 (2006.01); A61K 31/422 (2006.01); A61K 47/12 (2006.01); A61K 47/26 (2006.01); A61K 47/40 (2006.01); A61M 37/00 (2006.01); A61N 1/32 (2006.01)

CPC A61M 37/00 (2013.01) [A61K 9/7084 (2013.01); A61K 31/4045 (2013.01); A61K 31/4196 (2013.01); A61K 31/422 (2013.01); A61K 47/12 (2013.01); A61K 47/26 (2013.01); A61K 47/40 (2013.01); A61M 2037/0007 (2013.01); A61N 1/327 (2013.01)]

28 Claims

1. A method of treating a subject with a migraine, comprising:

opening a plurality of micropores in the subject's skin;

applying a patch to the subject's skin over the plurality of micropores for a period of time, wherein the patch comprises:

a top layer comprising an adhesive;

a middle layer comprising a triptan and a skin irritation reducer; and

a bottom layer, wherein the bottom layer comprises a release liner,

wherein a therapeutically effective amount of the triptan is delivered through the plurality of micropores during the period of time.