	US 12,324,869 B2
	Perforated tissue graft
Kevin Cornwell, Holliston, MA (US); and Kenneth James, Barton, VT (US)
Assigned to TEI BIOSCIENCES, INC., Boston, MA (US)
Filed by TEI Biosciences, Inc., Boston, MA (US)
Filed on Apr. 24, 2023, as Appl. No. 18/138,285.
Application 18/138,285 is a continuation of application No. 15/913,152, filed on Mar. 6, 2018, granted, now 11,633,520.
Claims priority of provisional application 62/467,503, filed on Mar. 6, 2017.
Prior Publication US 2023/0263940 A1, Aug. 24, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61L 27/36 (2006.01); A61K 35/34 (2015.01); A61K 35/36 (2015.01); A61K 35/44 (2015.01); A61L 27/56 (2006.01); C12N 5/00 (2006.01); C12N 5/077 (2010.01)

CPC A61L 27/3604 (2013.01) [A61K 35/34 (2013.01); A61K 35/36 (2013.01); A61K 35/44 (2013.01); A61L 27/3691 (2013.01); A61L 27/56 (2013.01); C12N 5/0068 (2013.01); A61L 27/3687 (2013.01); A61L 2430/40 (2013.01); C12N 5/0652 (2013.01); C12N 2533/54 (2013.01); C12N 2533/56 (2013.01); C12N 2533/90 (2013.01)]

20 Claims

1. A tissue graft configured for implanting on a mammal, the tissue graft comprising:

a sheet of a tissue graft material having a plurality of rows of small perforations, which pass through the sheet, and a plurality of rows of large perforations, which pass through the sheet;

wherein the small perforations have an internal volume that is less than 14.14 mm³and the large perforations have an internal volume that is equal to or greater than 14.14 mm³;

wherein the tissue graft material is acellular animal tissue;

wherein the rows of small perforations are substantially parallel to the rows of large perforations; and

wherein the rows of small perforations alternate with the rows of large perforations, such that one small perforation is centered about every four adjacent large perforations, which are arranged in a substantially square or rectangular manner about the one small perforation, and one large perforation is centered about every four adjacent small perforations, which are arranged in a substantially square or rectangular manner about the one large perforation.