US 12,324,866 B2
Method for preparing a tissue-adhesive sheet
Hubert Clemens Pellikaan, Utrecht (NL); Abraham Reinier Keereweer, Nijmegen (NL); and Johannes Caspar Mathias Elizabeth Bender, Nijmegen (NL)
Assigned to GATT Technologies B.V., Nijmegen (NL)
Filed by GATT TECHNOLOGIES B.V., Nijmegen (NL)
Filed on Jan. 11, 2022, as Appl. No. 17/573,541.
Application 17/573,541 is a continuation of application No. PCT/EP2020/069445, filed on Jul. 9, 2020.
Claims priority of application No. 19186041 (EP), filed on Jul. 12, 2019.
Prior Publication US 2022/0133948 A1, May 5, 2022
Int. Cl. A61L 24/00 (2006.01); D06M 10/00 (2006.01); D06M 10/10 (2006.01); D06M 15/356 (2006.01); D06M 15/53 (2006.01); D06M 15/564 (2006.01); D06M 23/08 (2006.01); D06M 23/14 (2006.01)
CPC A61L 24/0094 (2013.01) [A61L 24/0042 (2013.01); D06M 10/00 (2013.01); D06M 10/10 (2013.01); D06M 15/3562 (2013.01); D06M 15/53 (2013.01); D06M 15/564 (2013.01); D06M 23/08 (2013.01); D06M 23/14 (2013.01); A61L 2400/04 (2013.01)] 15 Claims
 
1. A method of preparing a tissue-adhesive sheet, comprising:
(a) providing a fibrous sheet comprising a three-dimensional interconnected interstitial space;
(b) providing reactive polymer particles comprising a water-soluble electrophilic polymer carrying at least 3 reactive electrophilic groups that are capable of reacting with amine groups in blood to form covalent bonds;
(c) placing the fibrous sheet and the reactive polymer particles between two electrodes;
(d) simultaneously subjecting the fibrous sheet and the reactive polymer particles to an electric field of 0.1 to 40 kV/mm to impregnate the interconnected interstitial space of the fibrous sheet with the reactive polymer particles.