US 12,324,861 B2
Beaded nonwoven membrane as a drug delivery system
Jose Antonio Tornero Garcia, Viladecavalls (ES); Francesc Cano Casas, Terrassa (ES); Luc Michelguy Marti Clausez, Barcelona (ES); and Joan Bertran Llavina, Arenys de Mar (ES)
Assigned to CEBIOTEX, S.L., Barcelona (ES)
Appl. No. 17/263,115
Filed by CEBIOTEX, S.L., Barcelona (ES)
PCT Filed Aug. 2, 2019, PCT No. PCT/EP2019/070887
§ 371(c)(1), (2) Date Jan. 25, 2021,
PCT Pub. No. WO2020/025793, PCT Pub. Date Feb. 6, 2020.
Claims priority of application No. 18382589 (EP), filed on Aug. 3, 2018.
Prior Publication US 2021/0154151 A1, May 27, 2021
Int. Cl. A61K 9/00 (2006.01); A61K 9/14 (2006.01); A61K 9/70 (2006.01); A61K 31/4745 (2006.01); D04H 1/435 (2012.01); D04H 1/728 (2012.01)
CPC A61K 9/7007 (2013.01) [A61K 9/146 (2013.01); A61K 31/4745 (2013.01); D04H 1/435 (2013.01); D04H 1/728 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A beaded nonwoven membrane comprising polymeric nanofibers, and at least one active agent, wherein:
(a) the nanofibers have a profile characterized by a series of nodulous segments having a bead-shaped morphology spaced from each other and distributed along a length of the nanofibers,
wherein the segments having the bead-shaped morphology are the segments of the nanofiber having a mean diameter that is 1.5 to 20 times greater than a mean diameter of segments of the nanofibers not having the bead-shaped morphology,
(b) the active agent has a water solubility equal to or lower than 33 mg/mL, and
(c) the total content of the active agent is physically entrapped by the membrane by being disposed in spaces between the polymeric nanofibers of the membrane such that no active agent is embedded within the polymeric nanofibers, including the nodulous segments with the bead-shaped morphology.