US 12,324,859 B2
Compounds and compositions for intracellular delivery of therapeutic agents
Kerry E. Benenato, Sudbury, MA (US); Ellalahewage Sathyajith Kumarasinghe, Harvard, MA (US); and Mark Cornebise, Arlington, MA (US)
Assigned to ModernaTX, Inc., Cambridge, MA (US)
Filed by ModernaTX, Inc., Cambridge, MA (US)
Filed on Sep. 23, 2020, as Appl. No. 17/029,436.
Application 17/029,436 is a continuation of application No. 16/382,423, filed on Apr. 12, 2019, granted, now 10,857,105.
Application 16/382,423 is a continuation of application No. PCT/US2018/022717, filed on Mar. 15, 2018.
Claims priority of provisional application 62/475,140, filed on Mar. 22, 2017.
Claims priority of provisional application 62/471,937, filed on Mar. 15, 2017.
Prior Publication US 2021/0154148 A1, May 27, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/127 (2025.01); A61K 9/51 (2006.01); A61K 31/7105 (2006.01); A61K 38/18 (2006.01); A61K 48/00 (2006.01); C07C 229/24 (2006.01)
CPC A61K 9/5123 (2013.01) [A61K 38/1816 (2013.01); A61K 48/0033 (2013.01); C07C 229/24 (2013.01); C07C 2601/04 (2017.05)] 11 Claims
 
1. A compound of Formula (IA):

OG Complex Work Unit Chemistry
or its N-oxide, or a salt or isomer thereof, wherein
l is selected from 1, 2, 3, 4, and 5;
m is selected from 5, 6, 7, 8, and 9;
M1 is a bond or M′;
R4 is

OG Complex Work Unit Chemistry
M and M′ are independently selected from —C(O)O— and —OC(O)—;
R2 and R3 are independently selected from the group consisting of C6-9 alkyl and C6-9 alkenyl; and
R′ is

OG Complex Work Unit Chemistry