| CPC A61K 8/9783 (2017.08) [A61K 8/0208 (2013.01); B44D 2/002 (2013.01); A61K 2800/43 (2013.01)] | 17 Claims |

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1. A substrate comprising:
an adhesive,
a hygroexpansible material,
a hygroinert ink,
wherein the hygroexpansible material is hydrophilic and the hygroinert ink is hydrophobic and wherein the hygroexpansible material forms a hygroexpansible layer and the hygroinert ink forms a hygroinert layer, wherein the hygroinert layer is disposed at least on a part of the hygroexpansible layer, and wherein the adhesive is comprised within an adhesive layer;
wherein the substrate comprises a first section comprising the adhesive, and a second section attached to the first section,
wherein the second section comprises a free end.
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