US 12,324,828 B2
Conjugates of a factor VIII moiety having an oxime-containing linkage
Mary J. Bossard, Madison, AL (US); and Dawei Sheng, Fremont, CA (US)
Assigned to Nektar Therapeutics, San Francisco, CA (US)
Filed by Nektar Therapeutics, San Francisco, CA (US)
Filed on Feb. 27, 2023, as Appl. No. 18/114,710.
Application 18/114,710 is a division of application No. 16/319,759, granted, now 11,628,205, previously published as PCT/US2017/043221, filed on Jul. 21, 2017.
Claims priority of provisional application 62/365,836, filed on Jul. 22, 2016.
Prior Publication US 2023/0241181 A1, Aug. 3, 2023
Int. Cl. A61K 38/37 (2006.01); A61K 47/54 (2017.01); A61K 47/60 (2017.01); C08G 65/331 (2006.01); C08G 65/332 (2006.01); C08G 65/333 (2006.01)
CPC A61K 38/37 (2013.01) [A61K 47/54 (2017.08); A61K 47/60 (2017.08); C08G 65/3314 (2013.01); C08G 65/3322 (2013.01); C08G 65/33306 (2013.01); C08G 65/33351 (2013.01); C08G 65/33396 (2013.01)] 4 Claims
 
1. A polymeric oxyamine reagent having a structure selected from:

OG Complex Work Unit Chemistry
where X is-NH(CH2)1-6NHC(O)CH2—, and each (n) ranges from about 1 to about 4,000.