	US 12,324,822 B2
	Method of treating type 2 diabetic patients
Yukiyasu Hayashi, Gifu (JP); and Chandan K. Sen, Columbus, OH (US)
Assigned to Osato International Inc., Gifu (JP)
Filed by OSATO INTERNATIONAL INC., Gifu (JP)
Filed on Dec. 10, 2020, as Appl. No. 17/117,647.
Application 17/117,647 is a continuation of application No. 15/062,912, filed on Mar. 7, 2016, abandoned.
Application 15/062,912 is a continuation of application No. PCT/JP2014/071810, filed on Aug. 20, 2014.
Prior Publication US 2021/0299200 A1, Sep. 30, 2021
Int. Cl. A61K 36/185 (2006.01); A61K 36/06 (2006.01); A61P 3/10 (2006.01)

CPC A61K 36/185 (2013.01) [A61K 36/06 (2013.01); A61P 3/10 (2018.01); A61K 2236/19 (2013.01)]

11 Claims

1. A method of promoting respiratory burst activity in a subject with type 2 diabetes without affecting blood glucose and total lipid levels of the subject with type 2 diabetes, the method comprising orally administering to the subject an effective amount of a fermented papaya preparation comprising:

91.2% carbohydrate,

3% protein,

2% lipid,

0149% potassium, and

water,

wherein the fermented papaya is the only anti-diabetic ingredient administered to the subject,

the effective amount of the fermented papaya preparation is 9 g/day per adult having a body weight of 70 kg, and

the method increases a production of reactive oxygen species (ROS) in the subject.