US 12,324,810 B2
3, 7-diamino-10H-phenothiazine salts and their use
Claude Michel Wischik, Aberdeen (GB); Janet Elizabeth Rickard, Aberdeen (GB); Charles Robert Harrington, Aberdeen (GB); David Horsley, Aberdeen (GB); John Mervyn David Storey, Aberdeen (GB); Colin Marshall, Aberdeen (GB); James Peter Sinclair, Aberdeen (GB); and Thomas Craven Baddeley, Aberdeen (GB)
Assigned to WisTa Laboratories Ltd., Singapore (SG)
Filed by WisTa Laboratories Ltd., Singapore (SG)
Filed on Mar. 5, 2024, as Appl. No. 18/595,985.
Application 14/929,111 is a division of application No. 14/248,730, filed on Apr. 9, 2014, granted, now 9,174,954.
Application 18/595,985 is a continuation of application No. 17/591,306, filed on Feb. 2, 2022, granted, now 11,951,110.
Application 17/591,306 is a continuation of application No. 14/929,111, filed on Oct. 30, 2015, granted, now 11,344,558.
Application 14/248,730 is a continuation of application No. 13/011,797, filed on Jan. 21, 2011, granted, now 8,710,051.
Application 13/011,797 is a continuation of application No. 12/294,599, granted, now 7,888,350, previously published as PCT/GB2007/001103, filed on Mar. 28, 2007.
Claims priority of provisional application 60/786,690, filed on Mar. 29, 2006.
Prior Publication US 2024/0245700 A1, Jul. 25, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/5415 (2006.01); C07D 279/20 (2006.01); C07D 279/22 (2006.01); C09B 21/00 (2006.01)
CPC A61K 31/5415 (2013.01) [C07D 279/20 (2013.01); C07D 279/22 (2013.01); C09B 21/00 (2013.01); Y02A 50/30 (2018.01)] 25 Claims
 
1. A method of treatment of fronto-temporal dementia in a subject in need thereof,
the method comprising administering to the subject a therapeutically effective amount of a bis protic acid salt compound of the following formula:

OG Complex Work Unit Chemistry
wherein:
each of R1 and R9 is independently selected from the group consisting of: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl;
each of R3NA and R3NB is independently selected from the group consisting of: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl;
each of R7NA and R7NB is independently selected from the group consisting of: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; and
each of HX1 and HX2 is independently a protic acid, wherein if any of HX1 or HX2 is a hydrohalic acid, then each is independently selected from the group consisting of HCl and HBr.