US 12,324,803 B2
3-(hydroxy)-pyridin-4(1H)-one compounds and methods of making and using the same
Adegboyega K. Oyelere, Atlanta, GA (US); Verjine Khodaverdian, Atlanta, GA (US); and Subhasish Tapadar, Atlanta, GA (US)
Assigned to Georgia Tech Research Corporation, Atlanta, GA (US)
Filed by Georgia Tech Research Corporation, Atlanta, GA (US)
Filed on Apr. 10, 2023, as Appl. No. 18/297,974.
Application 18/297,974 is a continuation of application No. 16/982,559, granted, now 11,654,137, previously published as PCT/US2019/023127, filed on Mar. 20, 2019.
Claims priority of provisional application 62/645,302, filed on Mar. 20, 2018.
Prior Publication US 2023/0255950 A1, Aug. 17, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/4439 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); C07D 401/06 (2006.01)
CPC A61K 31/4439 (2013.01) [A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07D 401/06 (2013.01)] 21 Claims
 
1. A compound according to Formula I:

OG Complex Work Unit Chemistry
wherein
A is —(CH2)n—, wherein n is from 2-8;
B is AR-AR′;
AR′ is a linking group connecting AR and A, and AR′ is selected from the group consisting of

OG Complex Work Unit Chemistry
AR is aryl, 6-membered aromatic, heterocyclic, fused aromatic, fused heterocyclic, biaromatic, or a biheterocyclic ring system, wherein the aryl, 6-membered aromatic, heterocyclic, fused aromatic, fused heterocyclic, biaromatic or biheterocyclic ring system is optionally substituted by halogen-, alkyl-, alkoxy-, haloalkyl-, alkylamino-, aryl-, heteroaryl-, alkenyl-, alkynyl- or X;
X is:

OG Complex Work Unit Chemistry
R1 is H or C1-C6 alkyl;
R2 is halogen, alkyl or aryl;
m is from 1-5; and
Y is alkyl or aryl,
or a hydrate thereof, or a solvate thereof, or a pharmaceutically acceptable salt thereof.