US 12,324,792 B2
Methods for making and using pharmaceutical compositions for iontophoresis
Mahyar Z. Kermani, San Ramon, CA (US)
Assigned to SMITH & NEPHEW, INC., Memphis, TN (US); SMITH & NEPHEW ORTHOPAEDICS AG, Zug (CH); and SMITH & NEPHEW ASIA PACIFIC PTE. LIMITED, Singapore (SG)
Filed by SMITH & NEPHEW, INC., Memphis, TN (US); SMITH & NEPHEW ORTHOPAEDICS AG, Zug (CH); and SMITH & NEPHEW ASIA PACIFIC PTE. LIMITED, Singapore (SG)
Filed on Nov. 5, 2021, as Appl. No. 17/520,053.
Claims priority of provisional application 63/131,099, filed on Dec. 28, 2020.
Prior Publication US 2022/0202749 A1, Jun. 30, 2022
Int. Cl. A61K 31/167 (2006.01); A61K 31/137 (2006.01); A61N 1/30 (2006.01)
CPC A61K 31/167 (2013.01) [A61K 31/137 (2013.01); A61N 1/30 (2013.01)] 29 Claims
OG exemplary drawing
 
1. A method comprising:
(a) selecting an isotonic pharmaceutical composition comprising
(i) charged ions of one or more active ingredients, and
(ii) competing ions of one or more non-active ingredients, wherein the isotonic pharmaceutical composition is operable for being used in an iontophoresis system to perform iontophoresis;
(b) removing at least 50% molar concentration of the competing ions from the isotonic pharmaceutical composition to produce a revised pharmaceutical composition; and
(c) utilizing the revised pharmaceutical composition in the iontophoresis system to perform iontophoresis.